Berisha Visar, Wang Shuai, LaCross Amy, Liss Julie
Department of Speech and Hearing Science, Arizona State University, Tempe, AZ, USA.
J Alzheimers Dis. 2015;45(3):959-63. doi: 10.3233/JAD-142763.
Changes in some lexical features of language have been associated with the onset and progression of Alzheimer's disease. Here we describe a method to extract key features from discourse transcripts, which we evaluated on non-scripted news conferences from President Ronald Reagan, who was diagnosed with Alzheimer's disease in 1994, and President George Herbert Walker Bush, who has no known diagnosis of Alzheimer's disease. Key word counts previously associated with cognitive decline in Alzheimer's disease were extracted and regression analyses were conducted. President Reagan showed a significant reduction in the number of unique words over time and a significant increase in conversational fillers and non-specific nouns over time. There was no significant trend in these features for President Bush.
语言某些词汇特征的变化与阿尔茨海默病的发病及进展有关。在此，我们描述一种从话语转录本中提取关键特征的方法，我们在罗纳德·里根总统（1994年被诊断患有阿尔茨海默病）和乔治·赫伯特·沃克·布什总统（无阿尔茨海默病确诊记录）的非脚本新闻发布会记录上对该方法进行了评估。提取了先前与阿尔茨海默病认知衰退相关的关键词计数，并进行了回归分析。里根总统随着时间推移独特词汇数量显著减少，对话填充词和非特定名词数量随时间显著增加。布什总统在这些特征上没有显著趋势。
