Han Xueling, Cui Hongyan, Chen Xu, Xie Wanying, Chang Ying
Department of Obstetrics, Tianjin Central Hospital of Obstetrics and Gynecology, No 156 Nankai Sanwei Street, Nankai District, Tianjin, 300100, China.
Arch Gynecol Obstet. 2015 Aug;292(2):291-8. doi: 10.1007/s00404-015-3635-z. Epub 2015 Jan 30.
Several studies have examined the association between glucokinase (GCK)-30G > A polymorphism and gestational diabetes mellitus (GDM). However, the results are still controversial. We performed the case-control study to investigate whether GCK-30G > A polymorphism correlates with the susceptibility of GDM in Chinese populations, and then conducted a meta-analysis by combining the previous studies.
We recruited 948 GDM patients and 975 controls from May 2011 to August 2013. All the subjects were genotyped using the PCR-based invader assay. The differences of allelic frequencies and genotype distributions between GDM patients and controls were investigated in case-control study. A systematic search of all relevant studies was conducted. The observational studies that were related to an association between the glucokinase (GCK)-30G > A polymorphism and GDM were identified. The association between the glucokinase (GCK)-30G > A polymorphism and GDM susceptibility was assessed using genetic models.
The case-control study showed that GCK-30G > A polymorphism was associated with the susceptibility of GDM in a Chinese population. Furthermore, other six previously reported studies were included to perform meta-analysis. The meta-analysis showed that GCK-30G > A polymorphism was associated with GDM in Caucasian and Asian.
This study suggested that GCK-30G > A polymorphism may be associated with the susceptibility of GDM in a Chinese population. The further meta-analysis provides additional evidence supporting the above result that the risk allele of the GCK-30G > A polymorphism may increase GDM risk.
多项研究探讨了葡萄糖激酶（GCK）-30G>A多态性与妊娠期糖尿病（GDM）之间的关联。然而，结果仍存在争议。我们进行了病例对照研究，以调查GCK-30G>A多态性是否与中国人群中GDM的易感性相关，然后结合先前的研究进行荟萃分析。
我们在2011年5月至2013年8月期间招募了948例GDM患者和975名对照。所有受试者均采用基于聚合酶链反应的侵入检测法进行基因分型。在病例对照研究中调查了GDM患者和对照之间等位基因频率和基因型分布的差异。对所有相关研究进行了系统检索。确定了与葡萄糖激酶（GCK）-30G>A多态性和GDM之间关联相关的观察性研究。使用遗传模型评估葡萄糖激酶（GCK）-30G>A多态性与GDM易感性之间的关联。
病例对照研究表明，GCK-30G>A多态性与中国人群中GDM的易感性相关。此外，纳入了其他六项先前报道的研究进行荟萃分析。荟萃分析表明，GCK-30G>A多态性与白种人和亚洲人中的GDM相关。
本研究表明，GCK-30G>A多态性可能与中国人群中GDM的易感性相关。进一步的荟萃分析提供了额外的证据支持上述结果，即GCK-30G>A多态性的风险等位基因可能增加GDM风险。
