Lawson Christina C, Johnson Candice Y, Chavarro Jorge E, Lividoti Hibert Eileen N, Whelan Elizabeth A, Rocheleau Carissa M, Grajewski Barbara, Schernhammer Eva S, Rich-Edwards Janet W
National Institute for Occupational Safety and Health 1090 Tusculum Ave, MS R-15, Cincinnati, OH 45226, USA.
Scand J Work Environ Health. 2015 Mar;41(2):194-203. doi: 10.5271/sjweh.3482. Epub 2015 Jan 29.
This study aimed to evaluate occupational exposures and menstrual cycle characteristics among nurses.
Using cross-sectional data collected in 2010-2012 from 6309 nurses aged 21-45 years, we investigated nurses' menstrual function in the Nurses' Health Study 3. We used multivariable regression modeling to analyze the associations between occupational exposures and prevalence of irregular cycles and long and short cycle lengths.
The cohort reported cycle length as <21 (1.5%), 21-25 (15.6%), 26-31 (69.7%), and 32-50 (13.2%) days. In addition, 19% of participants reported irregular cycles. Working ≥41 hours/week was associated with a 16% [95% confidence interval (95% CI): 4-29%] higher prevalence of irregular cycles and a higher prevalence of very short (<21-day) cycles [prevalence odds ratio (OR) 1.93, 95% CI 1.24-3.01] in adjusted models. Irregular menstrual cycles were more prevalent among women working nights only (32% higher; 95% CI 15-51%) or rotating nights (27% higher, 95% CI 10-47%), and was associated with the number of night shifts per month (P for trend <0.0001). Rotating night schedule was associated with long (32-50 day) cycles (OR 1.28, 95% CI 1.03-1.61). Heavy lifting was associated with a higher prevalence of irregular cycles (34% higher), and the prevalence of cycles <21 days and 21-25 day cycles increased with increasing heavy lifting at work (P for trend <0.02 for each endpoint).
Night work, long hours, and physically demanding work might relate to menstrual disturbances.
本研究旨在评估护士的职业暴露和月经周期特征。
利用2010年至2012年收集的6309名年龄在21至45岁之间护士的横断面数据，我们在护士健康研究3中调查了护士的月经功能。我们使用多变量回归模型分析职业暴露与月经周期不规律、周期长和周期短的患病率之间的关联。
该队列报告的月经周期长度为<21天（1.5%）、21至25天（15.6%）、26至31天（69.7%）和32至50天（13.2%）。此外，19%的参与者报告月经周期不规律。在调整模型中，每周工作≥41小时与月经周期不规律的患病率高16%[95%置信区间（95%CI）：4%至29%]以及极短（<21天）周期的患病率高相关[患病率比值比（OR）1.93，95%CI 1.24至3.01]。月经周期不规律在仅上夜班（高32%；95%CI 15%至51%）或轮值夜班（高27%，95%CI 10%至47%）的女性中更为普遍，并且与每月夜班次数相关（趋势P<0.0001）。轮值夜班时间表与长（32至50天）周期相关（OR 1.28，95%CI 1.03至
