Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Cell. 2015 Jan 29;160(3):363-4. doi: 10.1016/j.cell.2015.01.023.
To colonize the liver, colon cancer metastases must overcome hypoxia and other metabolic stress. Loo et al. now show that metastatic cells achieve this by decreasing miR-483 and miR-551a expression, which derepresses creatine kinase expression and allows energy to be captured from extracellular ATP through generation and import of phosphocreatine.
为了在肝脏中定植，结肠癌转移必须克服缺氧和其他代谢应激。Loo 等人现在表明，转移细胞通过降低 miR-483 和 miR-551a 的表达来实现这一点，这会解除肌酸激酶的表达抑制，从而通过生成和导入磷酸肌酸，从细胞外 ATP 中捕获能量。
