• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

与分枝杆菌一起变老。

Growing old with Myc.

作者信息

Carroll Patrick A, Eisenman Robert N

机构信息

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

出版信息

Cell. 2015 Jan 29;160(3):365-6. doi: 10.1016/j.cell.2015.01.018.

DOI:10.1016/j.cell.2015.01.018
PMID:25635453
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5425089/
Abstract

The Myc proto-oncogene has been intensively studied in tumorigenesis and development. A new paper in Cell reports the role of Myc as a determinant of mammalian longevity. Myc heterozygous mice exhibit extended lifespans resulting from alterations in multiple cellular processes distinct from those observed in other longevity models.

摘要

Myc原癌基因在肿瘤发生和发展过程中一直受到深入研究。《细胞》杂志上的一篇新论文报道了Myc作为哺乳动物寿命决定因素的作用。Myc杂合子小鼠的寿命延长，这是由多种细胞过程的改变导致的，这些改变与在其他长寿模型中观察到的不同。

相似文献

1
Growing old with Myc.与分枝杆菌一起变老。
Cell. 2015 Jan 29;160(3):365-6. doi: 10.1016/j.cell.2015.01.018.
2
Reduced expression of MYC increases longevity and enhances healthspan.MYC表达的降低可延长寿命并增强健康寿命。
Cell. 2015 Jan 29;160(3):477-88. doi: 10.1016/j.cell.2014.12.016. Epub 2015 Jan 22.
3
Haploinsufficiency of the Myc regulator Mtbp extends survival and delays tumor development in aging mice.Myc调节因子Mtbp的单倍剂量不足可延长衰老小鼠的生存期并延缓肿瘤发展。
Aging (Albany NY). 2016 Oct 30;8(10):2590-2602. doi: 10.18632/aging.101092.
4
Myc goes global: new tricks for an old oncogene.Myc走向全球：一个古老癌基因的新把戏。
Cancer Res. 2007 Jun 1;67(11):5061-3. doi: 10.1158/0008-5472.CAN-07-0426.
5
The Myc world within reach.触手可及的Myc世界。
Methods Mol Biol. 2013;1012:1-6. doi: 10.1007/978-1-62703-429-6_1.
6
Isoform-specific ras activation and oncogene dependence during MYC- and Wnt-induced mammary tumorigenesis.MYC和Wnt诱导的乳腺肿瘤发生过程中特定异构体的ras激活和癌基因依赖性。
Mol Cell Biol. 2006 Nov;26(21):8109-21. doi: 10.1128/MCB.00404-06. Epub 2006 Aug 14.
7
Failure of central nervous system myelination in MBP/c-myc transgenic mice: evidence for c-myc cytotoxicity.
Oncogene. 1998 Apr 23;16(16):2123-9. doi: 10.1038/sj.onc.1201739.
8
Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis.Bax缺失会损害Myc诱导的细胞凋亡，并在Myc介导的淋巴瘤发生过程中规避p53突变的选择。
Mol Cell Biol. 2001 Nov;21(22):7653-62. doi: 10.1128/MCB.21.22.7653-7662.2001.
9
Critical role of Myc activation in mouse hepatocarcinogenesis induced by the activation of AKT and RAS pathways.Myc激活在由AKT和RAS途径激活诱导的小鼠肝癌发生中的关键作用。
Oncogene. 2017 Sep 7;36(36):5087-5097. doi: 10.1038/onc.2017.114. Epub 2017 May 8.
10
C-myc overexpression drives melanoma metastasis by promoting vasculogenic mimicry via c-myc/snail/Bax signaling.C-myc过表达通过c-myc/蜗牛蛋白/Bax信号通路促进血管生成拟态，从而驱动黑色素瘤转移。
J Mol Med (Berl). 2017 Jan;95(1):53-67. doi: 10.1007/s00109-016-1452-x. Epub 2016 Aug 19.

引用本文的文献

1
Genes and Longevity of Lifespan.基因与寿命的长短。
Int J Mol Sci. 2022 Jan 28;23(3):1499. doi: 10.3390/ijms23031499.
2
Exerts an Anticancer Effect on Human Osteosarcoma Cells via Suppressing the Wnt/β-Catenin Signaling Pathway.通过抑制 Wnt/β-连环蛋白信号通路对人骨肉瘤细胞发挥抗癌作用。
Integr Cancer Ther. 2019 Jan-Dec;18:1534735419890917. doi: 10.1177/1534735419890917.
3
Antitumor activity of resveratrol against human osteosarcoma cells: a key role of Cx43 and Wnt/β-catenin signaling pathway.白藜芦醇对人骨肉瘤细胞的抗肿瘤活性：Cx43和Wnt/β-连环蛋白信号通路的关键作用
Oncotarget. 2017 Nov 30;8(67):111419-111432. doi: 10.18632/oncotarget.22810. eCollection 2017 Dec 19.

本文引用的文献

1
Reduced expression of MYC increases longevity and enhances healthspan.MYC表达的降低可延长寿命并增强健康寿命。
Cell. 2015 Jan 29;160(3):477-88. doi: 10.1016/j.cell.2014.12.016. Epub 2015 Jan 22.
2
Inactivation of p53 in Human Keratinocytes Leads to Squamous Differentiation and Shedding via Replication Stress and Mitotic Slippage.人角质形成细胞中p53的失活通过复制应激和有丝分裂滑移导致鳞状分化和脱落。
Cell Rep. 2014 Nov 20;9(4):1349-60. doi: 10.1016/j.celrep.2014.10.012. Epub 2014 Nov 6.
3
Myc-dependent genome instability and lifespan in Drosophila.果蝇中 Myc 依赖性基因组不稳定性和寿命。
PLoS One. 2013 Sep 6;8(9):e74641. doi: 10.1371/journal.pone.0074641. eCollection 2013.
4
mTOR is a key modulator of ageing and age-related disease.mTOR 是衰老和与年龄相关疾病的关键调节剂。
Nature. 2013 Jan 17;493(7432):338-45. doi: 10.1038/nature11861.
5
Genetics of longevity in model organisms: debates and paradigm shifts.模式生物长寿的遗传学：争论与范式转变。
Annu Rev Physiol. 2013;75:621-44. doi: 10.1146/annurev-physiol-030212-183712. Epub 2012 Nov 26.
6
Modulation of longevity and tissue homeostasis by the Drosophila PGC-1 homolog.果蝇 PGC-1 同源物对寿命和组织稳态的调节。
Cell Metab. 2011 Nov 2;14(5):623-34. doi: 10.1016/j.cmet.2011.09.013.
7
Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients.禁食与饮食限制在细胞保护和癌症治疗中的作用：从模式生物到患者。
Oncogene. 2011 Jul 28;30(30):3305-16. doi: 10.1038/onc.2011.91. Epub 2011 Apr 25.
8
Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity.造血干细胞的功能和存活依赖于c-Myc和N-Myc的活性。
Cell Stem Cell. 2008 Dec 4;3(6):611-24. doi: 10.1016/j.stem.2008.09.005.
9
The transcriptional repressor dMnt is a regulator of growth in Drosophila melanogaster.转录抑制因子dMnt是黑腹果蝇生长的调节因子。
Mol Cell Biol. 2005 Aug;25(16):7078-91. doi: 10.1128/MCB.25.16.7078-7091.2005.