Ades Philip A, Savage Patrick D, Marney Annis M, Harvey Jean, Evans Kimberly A
Divisions of Cardiology (Dr Ades and Mr Savage), Endocrinology (Dr Marney), and Nutrition and Food Sciences (Dr Harvey and Ms Evans), University of Vermont Medical Center, Burlington, Vermont.
J Cardiopulm Rehabil Prev. 2015 May-Jun;35(3):193-7. doi: 10.1097/HCR.0000000000000106.
To determine the rate of remission of recently diagnosed (<1 year) type 2 diabetes mellitus (T2DM) in overweight/obese individuals, with a 6-month program of weight loss and exercise.
Subjects (N = 12) were overweight/obese (body mass index = 35.8 ± 4.3 kg/m), sedentary, and unfit ((Equation is included in full-text article.)O2peak = 20.7 ± 4.7 mL·kg·min) and recently (<1 year) diagnosed with T2DM. They were willing to participate in a lifestyle program of behavioral weight loss counseling and supervised exercise located at a cardiac rehabilitation program prior to consideration of diabetes medications. Glycated hemoglobin (HbA1c) level before and after the study intervention was the primary study outcome, along with secondary metabolic, fitness, and body composition variables.
Subjects had a baseline HbA1c of 6.5% to 8.0% (mean 6.8 ± 0.2). Subjects lost 9.7 ± 0.2 kg body weight (9%) and improved peak aerobic capacity by 18%. Two subjects withdrew for medical reasons unrelated to the lifestyle program. Eight of 10 completers (80%) went into partial T2DM remission, with the mean HbA1c decreasing from 6.8 ± 0.2% to 6.2 ± 0.3% (P < .001).
For individuals with recently diagnosed T2DM willing to undertake a formal lifestyle program, 80% of study completers and 67% of our total population achieved at least a partial T2DM remission at 6 months. Further study of this intervention at the time of diagnosis of T2DM with randomized controls and longer-term followup is warranted.
通过一项为期6个月的减肥和运动计划，确定超重/肥胖个体中近期诊断（<1年）的2型糖尿病（T2DM）的缓解率。
受试者（N = 12）超重/肥胖（体重指数 = 35.8 ± 4.3 kg/m），久坐不动且身体不健康（（全文包含公式）氧峰值 = 20.7 ± 4.7 mL·kg·min），且近期（<1年）被诊断为T2DM。在考虑使用糖尿病药物之前，他们愿意参加一项位于心脏康复项目中的行为减肥咨询和监督运动的生活方式计划。研究干预前后的糖化血红蛋白（HbA1c）水平是主要研究结果，同时还有次要的代谢、健康和身体成分变量。
受试者的基线HbA1c为6.5%至8.0%（平均6.8 ± 0.2）。受试者体重减轻了9.7 ± 0.2 kg（9%），有氧能力峰值提高了18%。两名受试者因与生活方式计划无关的医疗原因退出。10名完成者中有8名（占80%）进入T2DM部分缓解状态，平均HbA1c从6.8 ± 0.2%降至6.2 ± 0.3%（P < .001）。
对于愿意接受正式生活方式计划的近期诊断为T2DM的个体，80%的研究完成者和67%的总人群在6个月时至少实现了T2DM的部分缓解。在T2DM诊断时采用随机对照和长期随访对该干预措施进行进一步研究是有必要的。
