Carlozzi Noelle E, Kratz Anna L, Downing Nancy R, Goodnight Siera, Miner Jennifer A, Migliore Nicholas, Paulsen Jane S
Department of Physical Medicine and Rehabilitation, University of Michigan, North Campus Research Complex, 2800 Plymouth Road, Ann Arbor, MI, 48109-2800, USA,
Qual Life Res. 2015 Aug;24(8):1963-71. doi: 10.1007/s11136-015-0930-x. Epub 2015 Jan 31.
The reliability and construct validity of the 12-item World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) were examined in individuals with Huntington disease (HD).
We examined factor structure (confirmatory factor analysis), internal consistency reliability (Cronbach's alpha), floor and ceiling effects, convergent validity (Pearson correlations), and known-groups validity (multivariate analysis).
Results of a confirmatory factor analysis replicated the six-factor latent model that reflects the six separate scales within the WHODAS 2.0 (understanding and communicating; getting around; self-care; getting along with others; life activities; participation). Cronbach's alpha for the scale was 0.94, suggesting good internal consistency reliability. The WHODAS demonstrated a ceiling effect for 19.5 % of participants; there were no floor effects. There was evidence for convergent validity; the WHODAS demonstrated moderate significant correlations with other general measures of health-related quality of life (HRQOL; i.e., RAND-12, EQ5D). Multivariate analyses indicated that late-stage HD participants indicated poorer HRQOL than both early-stage HD and prodromal HD participants for all HRQOL measures.
Findings provide support for both the reliability and validity of the WHODAS 2.0 in individuals with HD.
在亨廷顿舞蹈症（HD）患者中检验12项世界卫生组织残疾评定量表2.0（WHODAS 2.0）的信度和结构效度。
我们检验了因子结构（验证性因子分析）、内部一致性信度（克朗巴哈系数）、地板效应和天花板效应、收敛效度（皮尔逊相关性）以及已知群组效度（多变量分析）。
验证性因子分析结果重现了反映WHODAS 2.0中六个独立量表（理解与交流；四处活动；自我照料；与他人相处；生活活动；参与）的六因子潜在模型。该量表的克朗巴哈系数为0.94，表明具有良好的内部一致性信度。WHODAS在19.5%的参与者中显示出天花板效应；未出现地板效应。有证据支持收敛效度；WHODAS与其他健康相关生活质量（HRQOL）的一般测量指标（即RAND-12、EQ5D）呈中度显著相关。多变量分析表明，在所有HRQOL测量指标上，HD晚期参与者的HRQOL均比HD早期参与者和前驱期HD参与者差。
研究结果为WHODAS 2.0在HD患者中的信度和效度提供了支持。
