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山竹（Garcinia mangostana Linn.）成分对醛糖还原酶的体外抑制活性

The inhibitory activity of aldose reductase in vitro by constituents of Garcinia mangostana Linn.

作者信息

Fatmawati Sri, Ersam Taslim, Shimizu Kuniyoshi

机构信息

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Sepuluh Nopember, Kampus ITS-Sukolilo, Surabaya 60111, Indonesia.

Department of Chemistry, Faculty of Mathematics and Natural Sciences, Institut Teknologi Sepuluh Nopember, Kampus ITS-Sukolilo, Surabaya 60111, Indonesia.

出版信息

Phytomedicine. 2015 Jan 15;22(1):49-51. doi: 10.1016/j.phymed.2014.11.001. Epub 2014 Nov 20.

DOI:10.1016/j.phymed.2014.11.001
PMID:25636870
Abstract

We investigated aldose reductase inhibition of Garcinia mangostana Linn. from Indonesia. Dichloromethane extract of the root bark of this tree was found to demonstrate an IC50 value of 11.98 µg/ml for human aldose reductase in vitro. From the dichloromethane fraction, prenylated xanthones were isolated as potent human aldose reductase inhibitors. We discovered 3-isomangostin to be most potent against aldose reductase, with an IC50 of 3.48 µM.

摘要

我们研究了来自印度尼西亚的山竹（Garcinia mangostana Linn.）的醛糖还原酶抑制作用。发现该树种根皮的二氯甲烷提取物在体外对人醛糖还原酶的IC50值为11.98 µg/ml。从二氯甲烷馏分中分离出了异戊烯基氧杂蒽酮作为有效的人醛糖还原酶抑制剂。我们发现3-异山竹素对醛糖还原酶的抑制作用最强，IC50为3.48 µM。

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