肥胖中的微小RNA -143和-223
MicroRNA -143 and -223 in obesity.
作者信息
Kilic Ismail Dogu, Dodurga Yavuz, Uludag Burcu, Alihanoglu Yusuf I, Yildiz Bekir Serhat, Enli Yasar, Secme Mucahit, Bostancı H Eren
机构信息
Pamukkale University, Medical Faculty, Department of Cardiology, Denizli, Turkey.
Pamukkale University, Medical Faculty, Department of Medical Biology, Denizli, Turkey.
出版信息
Gene. 2015 Apr 15;560(2):140-2. doi: 10.1016/j.gene.2015.01.048. Epub 2015 Jan 28.
BACKGROUND
Obesity alters endocrine and metabolic functions of adipose tissue and has been recognized as a chronic inflammatory disease, which in turn may contribute to the development of insulin resistance, type 2 diabetes, obesity-associated vasculopathy and cardiovascular disease. The pathogenesis of obesity involves many regulatory pathways including transcriptional regulatory networks, including microRNAs.
METHODS
A total of 83 patients were included in the study. Patients were recruited from a cardiology outpatient clinic and were allocated into 3 age- and sex-matched groups according to their body mass index. Group 1 included 23 morbidly obese, group 2 30 obese, and group 3 30 normal or overweight subjects.
RESULTS
In our study, we showed that miR-143 and miR-223 levels were significantly lower in groups 1 and 2 than the control group (normal BMI or overweight).
CONCLUSIONS
Obesity leads to alterations in miRNA expressions and miRNA-143 and -223s can be used as biomarkers for the metabolic changes in obesity.
背景
肥胖会改变脂肪组织的内分泌和代谢功能，并且已被公认为是一种慢性炎症性疾病，进而可能促使胰岛素抵抗、2型糖尿病、肥胖相关血管病变和心血管疾病的发生。肥胖的发病机制涉及许多调控途径，包括转录调控网络，其中就有微小RNA。
方法
本研究共纳入83例患者。这些患者来自心脏病门诊，根据体重指数被分为3个年龄和性别匹配的组。第1组包括23例病态肥胖者，第2组30例肥胖者，第3组30例正常或超重受试者。
结果
在我们的研究中，我们发现第1组和第2组中miR-143和miR-223的水平显著低于对照组（正常体重指数或超重）。
结论
肥胖会导致微小RNA表达的改变，且miR-143和-223可作为肥胖代谢变化的生物标志物。
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