Bailey N W, Hoy K E, Maller J J, Upton D J, Segrave R A, Fitzgibbon B M, Fitzgerald P B
Monash Alfred Psychiatry Research Centre, Alfred Hospital and Monash University, School of Psychology, Psychiatry and Psychological Medicine, Melbourne, VIC, Australia.
Monash Alfred Psychiatry Research Centre, Alfred Hospital and Monash University, School of Psychology, Psychiatry and Psychological Medicine, Melbourne, VIC, Australia.
Biol Psychol. 2015 Mar;106:1-10. doi: 10.1016/j.biopsycho.2015.01.011. Epub 2015 Jan 28.
Impaired error awareness is related to poorer outcome following traumatic brain injury (TBI). Error awareness deficits are also found in major depressive disorder (MDD), but have not been examined in the MDD that follows a TBI (TBI-MDD). This study assessed neural activity related to error awareness in TBI-MDD. Four groups completed a response inhibition task while EEG was recorded- healthy controls (N = 15), MDD-only (N = 15), TBI-only (N = 16), and TBI-MDD (N = 12). Error related EEG activity was compared using powerful randomisation statistics that included all electrodes and time points. Participants with TBI-MDD displayed less frontally distributed neural activity, suggesting reduced contribution from frontal generating sources. Neural activity during this time window is thought to reflect conscious awareness of errors. The TBI-only and MDD-only groups did not differ from controls, and early error processing was unaffected, suggesting early error detection is intact.
错误意识受损与创伤性脑损伤（TBI）后较差的预后相关。在重度抑郁症（MDD）中也发现了错误意识缺陷，但尚未在创伤性脑损伤后发生的重度抑郁症（TBI-MDD）中进行研究。本研究评估了与TBI-MDD中错误意识相关的神经活动。四组在记录脑电图时完成了反应抑制任务——健康对照组（N = 15）、仅患有MDD组（N = 15）、仅患有TBI组（N = 16）和TBI-MDD组（N = 12）。使用包括所有电极和时间点的强大随机化统计方法比较了与错误相关的脑电图活动。患有TBI-MDD的参与者额叶分布的神经活动较少，这表明额叶产生源的贡献减少。这个时间窗口内的神经活动被认为反映了对错误的意识。仅患有TBI组和仅患有MDD组与对照组没有差异，并且早期错误处理未受影响，这表明早期错误检测是完整的。
