Bailey Neil W, Rogasch Nigel C, Hoy Kate E, Maller Jerome J, Segrave Rebecca A, Sullivan Caley M, Fitzgerald Paul B
a Monash Alfred Psychiatry Research Centre , Alfred Hospital and Central Clinical School, Monash University , Melbourne , VIC , Australia.
b Monash Clinical and Imaging Neuroscience, School of Psychological Science and Monash Biomedical Imaging , Monash University , Melbourne , Australia.
Brain Inj. 2017;31(3):379-389. doi: 10.1080/02699052.2016.1239273. Epub 2017 Jan 17.
Alterations to functional connectivity following a traumatic brain injury (TBI) may lead to impaired cognitive performance and major depressive disorder (MDD). In particular, functional gamma band connectivity is thought to reflect information binding important for working memory. The objective of this study was to determine whether altered functional gamma connectivity may be a factor in MDD following TBI (TBI-MDD).
This study assessed individuals with TBI-MDD, as well as individuals with TBI alone and MDD alone using electroencephalographic recordings while participants performed a working memory task to assess differences in functional connectivity between these groups.
Functional connectivity was compared using the debiased weighted phase lag index (wPLI). wPLI was measured from a group of healthy controls (n = 31), participants with MDD (n = 17), participants with TBI (n = 20) and participants with TBI-MDD (n = 15).
Contrary to the predictions, this study found both the groups with TBI and TBI-MDD showed higher gamma connectivity from posterior regions during WM retention.
This may reflect dysfunctional functional connectivity in these groups, as a result of maladaptive neuroplastic reorganization.
创伤性脑损伤（TBI）后功能连接的改变可能导致认知能力受损和重度抑郁症（MDD）。特别是，功能性γ波段连接被认为反映了对工作记忆很重要的信息绑定。本研究的目的是确定功能性γ连接的改变是否可能是TBI后MDD（TBI-MDD）的一个因素。
本研究使用脑电图记录评估了患有TBI-MDD的个体，以及仅患有TBI和仅患有MDD的个体，同时参与者执行一项工作记忆任务，以评估这些组之间功能连接的差异。
使用去偏加权相位滞后指数（wPLI）比较功能连接。wPLI是从一组健康对照者（n = 31）、患有MDD的参与者（n = 17）、患有TBI的参与者（n = 20）和患有TBI-MDD的参与者（n = 15）中测量的。
与预测相反，本研究发现患有TBI和TBI-MDD的两组在工作记忆保持期间后脑部区域的γ连接性更高。
这可能反映了这些组中功能连接的功能失调，这是适应性不良的神经可塑性重组的结果。
