Shang Wei, Wang Aiming, Lv Libo, Zhang Lei, Shu Mingming, Zhao Yong, Hui Shang
The In Vitro Fertility Center of Obstetrics & Gynecology, PLA Navy General Hospital, Beijing, 100048, China.
Center of Obstetrics & Gynecology, PLA General Navy Hospital, No. 6 Fucheng Road, Haidian District, Beijing, 100048, China.
Cell Biochem Biophys. 2015 Jul;72(3):817-20. doi: 10.1007/s12013-015-0539-2.
Our goal was to develop a safe, efficient, and practical clinical plan for successful pregnancies for patients with recurrent spontaneous miscarriages by adjustment of their hormone levels after ovulation. We treated 61 patients with recurrent miscarriages and 110 patients with two miscarriages. All patients had miscarriages before or during the 12th week of pregnancy, and unsuccessfully underwent progesterone therapy. We measured their hormone levels and administered appropriate doses of estrogen, progesterone, and luteinizing hormones to attain normal levels (respectively, 150 pg/ml, 16 ng/ml, and 6 mIU/ml). The hormone doses were reduced upon detection of fetal heart beating, and the treatment continued until the 12th week of pregnancy. The patients were followed up by phone after the child birth. In patients with recurrent miscarriages, these were prevented in 57/61 (93.44 %). In patients with two miscarriages, successful pregnancies were in 106/110 (96.4 %) patients. The vast majority of patients in both groups gave birth to healthy babies. There was only one case per each group of induced labor due to trisomy 21 (patient with a history of recurrent miscarriages) or trisomy 17 (patient with two previous miscarriages). Individualized adjustment of hormone levels after ovulation prevents miscarriages and improves the pregnancy success rates.
我们的目标是通过调整排卵后的激素水平，为复发性自然流产患者制定一个安全、有效且实用的临床方案，以实现成功妊娠。我们治疗了61例复发性流产患者和110例有两次流产史的患者。所有患者在妊娠第12周之前或期间均有流产经历，且接受黄体酮治疗未成功。我们测量了他们的激素水平，并给予适当剂量的雌激素、黄体酮和促黄体生成素，使其达到正常水平（分别为150 pg/ml、16 ng/ml和6 mIU/ml）。检测到胎心后减少激素剂量，治疗持续至妊娠第12周。产后通过电话对患者进行随访。在复发性流产患者中，57/61（93.44%）的患者未再发生流产。在有两次流产史的患者中，106/110（96.4%）的患者成功妊娠。两组中的绝大多数患者都生下了健康的婴儿。每组仅各有1例因21三体（有复发性流产史的患者）或17三体（有两次既往流产史的患者）引产。排卵后进行个体化激素水平调整可预防流产并提高妊娠成功率。
