肥胖成人接受胃旁路手术或强化生活方式治疗后睡眠药物使用情况的变化
Change in Use of Sleep Medications After Gastric Bypass Surgery or Intensive Lifestyle Treatment in Adults with Obesity.
作者信息
Ng Winda L, Peeters Anna, Näslund Ingmar, Ottosson Johan, Johansson Kari, Marcus Claude, Shaw Jonathan E, Bruze Gustaf, Sundström Johan, Neovius Martin
机构信息
Department of Medicine, Solna, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden.
Clinical Diabetes and Epidemiology, Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
出版信息
Obesity (Silver Spring). 2017 Aug;25(8):1451-1459. doi: 10.1002/oby.21908. Epub 2017 Jun 29.
OBJECTIVE
To examine the change in use of hypnotics and/or sedatives after gastric bypass surgery or intensive lifestyle modification in adults with obesity.
METHODS
Adults with obesity who underwent gastric bypass surgery or initiated intensive lifestyle modification between 2007 and 2012 were identified through the Scandinavian Obesity Surgery Registry and a Swedish commercial weight loss database. The two cohorts were matched on BMI, age, sex, education, history of hypnotics and/or sedatives use, and treatment year (surgery n = 20,626; lifestyle n = 11,973; 77% women, mean age 41 years, mean BMI 41 kg/m ). The proportion of participants with filled hypnotics and/or sedatives prescriptions was compared yearly for 3 years.
RESULTS
In the matched treatment cohorts, 4% had filled prescriptions for hypnotics and/or sedatives during the year before treatment. At 1 year follow-up, following an average weight loss of 37 kg and 18 kg in the surgery and intensive lifestyle cohorts, respectively, this proportion had increased to 7% in the surgery cohort but remained at 4% in the intensive lifestyle cohort (risk ratio 1.7; 95% CI: 1.4-2.1); at 2 years, the proportion had increased to 11% versus 5% (risk ratio 2.0; 95% CI: 1.7-2.4); and at 3 years, it had increased to 14% versus 6% (risk ratio 2.2; 95% CI: 1.9-2.6).
CONCLUSIONS
Gastric bypass surgery was associated with increased use of hypnotics and/or sedatives compared with intensive lifestyle modification.
目的
研究肥胖成年人接受胃旁路手术或强化生活方式改变后催眠药和/或镇静剂的使用变化。
方法
通过斯堪的纳维亚肥胖手术登记处和瑞典一个商业减肥数据库，确定了2007年至2012年间接受胃旁路手术或开始强化生活方式改变的肥胖成年人。这两个队列在体重指数、年龄、性别、教育程度、催眠药和/或镇静剂使用史以及治疗年份方面进行了匹配（手术组n = 20,626；生活方式组n = 11,973；77%为女性，平均年龄41岁，平均体重指数41 kg/m²）。对参与者开具催眠药和/或镇静剂处方的比例进行了为期3年的年度比较。
结果
在匹配的治疗队列中，4%的参与者在治疗前一年开具了催眠药和/或镇静剂处方。在1年随访时，手术组和强化生活方式组的平均体重分别减轻了37 kg和18 kg，手术组这一比例增至7%，而强化生活方式组仍为4%（风险比1.7；95%置信区间：1.4 - 2.1）；在2年时，该比例分别增至11%和5%（风险比2.0；95%置信区间：1.7 - 2.4）；在3年时，分别增至14%和6%（风险比2.2；95%置信区间：1.9 - 2.6）。
结论
与强化生活方式改变相比，胃旁路手术与催眠药和/或镇静剂使用增加有关。
Zotero 插件