Armignacco Paolo, Lorenzin Anna, Neri Mauro, Nalesso Federico, Garzotto Francesco, Ronco Claudio
International Renal Research Institute, Vicenza, Italy.
Semin Dial. 2015 Mar-Apr;28(2):125-30. doi: 10.1111/sdi.12346. Epub 2015 Jan 30.
The prevalences of end-stage renal disease (ESRD) and renal replacement therapy (RRT) continue to increase across the world imposing staggering costs on providers. Therefore, strategies to optimize the treatment and improve survival are of fundamental importance. Despite the benefits of daily dialysis, its implementation is difficult and wearable hemodialysis might represent an alternative by which frequent treatments can be delivered to ESRD patients with much less interference in their routines promoting better quality of life. The development of the wearable artificial kidney (WAK) requires incorporation of basic components of a dialysis system into a wearable device that allows mobility, miniaturization, and above all, patient-oriented management. The technical requirements necessary for WAK can be divided into the following broad categories: dialysis membranes, dialysis regeneration, vascular access, patient monitoring systems, and power sources. Pumping systems for blood and other fluids are the most critical components of the entire device.
终末期肾病（ESRD）和肾脏替代疗法（RRT）在全球的患病率持续上升，给医疗服务提供者带来了惊人的成本。因此，优化治疗和提高生存率的策略至关重要。尽管每日透析有诸多益处，但其实施困难，而可穿戴血液透析可能是一种替代方案，通过它可以为ESRD患者提供更频繁的治疗，且对其日常生活的干扰要少得多，从而提高生活质量。可穿戴人工肾（WAK）的研发需要将透析系统的基本组件整合到一个可穿戴设备中，该设备要具备移动性、小型化，最重要的是要以患者为导向进行管理。WAK所需的技术要求可大致分为以下几大类：透析膜、透析再生、血管通路、患者监测系统和电源。血液及其他液体的泵送系统是整个设备最关键的组件。
