Ronco Claudio, Davenport Andrew, Gura Victor
Department of Nephrology, Ospedale San Bortolo, Vicenza, Italy.
Hemodial Int. 2008 Jul;12 Suppl 1:S40-7. doi: 10.1111/j.1542-4758.2008.00295.x.
The evolution of technology in hemodialysis has gone through several steps including the feasibility phase, the search for reliability, the implementation of automation to improve efficiency and the quest towards increased tolerance and treatment adequacy. Today, a new challenge is appearing on the scene and it concerns miniaturization, transportability, wearability and the possibility of developing implantable devices for renal replacement therapies. Although we are not there yet, a new series of papers have recently been published disclosing interesting and promising results on the application of wearable ultrafiltration systems (WUF) and wearable artificial kidneys (WAK). Some of these use extracorporeal blood cleansing as a method of blood purification while others use peritoneal dialysis as a treatment modality. This manuscript presents the initial results with these new devices and proposes an effort to make a quantum leap in technology making the wearable artificial kidney a reality rather than a dream.
血液透析技术的发展经历了几个阶段，包括可行性阶段、寻求可靠性阶段、实施自动化以提高效率阶段以及追求更高耐受性和治疗充分性阶段。如今，一个新的挑战正在出现，它涉及小型化、可运输性、可穿戴性以及开发用于肾脏替代疗法的植入式设备的可能性。尽管我们尚未实现，但最近发表了一系列新论文，披露了关于可穿戴超滤系统（WUF）和可穿戴人工肾（WAK）应用的有趣且有前景的结果。其中一些使用体外血液净化作为血液净化方法，而另一些则使用腹膜透析作为治疗方式。本手稿展示了这些新设备的初步结果，并提出努力实现技术上的巨大飞跃，使可穿戴人工肾成为现实而非梦想。
