Xu Xin-Sen, Miao Run-Chen, Wan Yong, Zhang Ling-Qiang, Qu Kai, Liu Chang
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China E-mail :
Asian Pac J Cancer Prev. 2015;16(1):23-9. doi: 10.7314/apjcp.2015.16.1.23.
Current cancer therapy mainly focuses on identifying novel targets crucial for tumorigenesis. The FoxM1 is of preference as an anticancer target, due to its significance in execution of mitosis, cell cycle progression, as well as other signal pathways leading to tumorigenesis. FoxM1 is partially regulated by oncoproteins or tumor suppressors, which are often mutated, lost, or overexpressed in human cancer. Since sustaining proliferating signaling is an important hallmark of cancer, FoxM1 is overexpressed in a series of human malignancies. Alarge- scale gene expression analysis also identified FoxM1 as a differentially-expressed gene in most solid tumors. Furthermore, overexpressed FoxM1 is correlated with the prognosis of cancer patients, as verified in a series of malignancies by Cox regression analysis. Thus, extensive studies have been conducted to explore the roles of FoxM1 in tumorigenesis, making it an attractive target for anticancer therapy. Several antitumor drugs have been reported to target or inhibit FoxM1 expression in different cancers, and down-regulation of FoxM1 also abrogates drug resistance in some cancer cell lines, highlighting a promising future for FoxM1 application in the clinic.
当前的癌症治疗主要集中在识别对肿瘤发生至关重要的新靶点。FoxM1作为抗癌靶点备受青睐，因为它在有丝分裂的执行、细胞周期进程以及其他导致肿瘤发生的信号通路中具有重要意义。FoxM1部分受癌蛋白或肿瘤抑制因子调控，而这些因子在人类癌症中常常发生突变、缺失或过表达。由于维持增殖信号是癌症的一个重要特征，FoxM1在一系列人类恶性肿瘤中过表达。大规模基因表达分析也将FoxM1鉴定为大多数实体瘤中的差异表达基因。此外，通过Cox回归分析在一系列恶性肿瘤中证实，过表达的FoxM1与癌症患者的预后相关。因此，人们已经进行了广泛的研究来探索FoxM1在肿瘤发生中的作用，使其成为抗癌治疗的一个有吸引力的靶点。据报道，几种抗肿瘤药物在不同癌症中靶向或抑制FoxM1表达，并且FoxM1的下调也消除了一些癌细胞系中的耐药性，这凸显了FoxM1在临床上应用的广阔前景。
