Fink Christine, Enk Alexander, Gholam Patrick
Department of Dermatology, University of Heidelberg, Heidelberg, Germany.
J Dtsch Dermatol Ges. 2015 Jan;13(1):15-22. doi: 10.1111/ddg.12546.
Topical photodynamic therapy (PDT) is a highly effective and safe treatment method for actinic keratoses with an excellent cosmetic outcome and is commonly used for the therapy of large areas of photodamaged skin with multiple clinically manifest and subclinical lesions. However, the major drawback of photodynamic therapy is the pain experienced during the treatment that can be intense and sometimes even intolerable for patients, requiring interruption or termination of the process. Several strategies for controlling pain during photodynamic therapy have been studied but few effective methods are currently available. Therefore, this review puts the spotlight on predictors on pain intensity and aspects of pain management during photodynamic therapy.
局部光动力疗法（PDT）是治疗光化性角化病的一种高效且安全的方法，具有极佳的美容效果，常用于治疗大面积存在多个临床显性和亚临床病变的光损伤皮肤。然而，光动力疗法的主要缺点是治疗过程中会产生疼痛，这种疼痛可能很剧烈，有时甚至让患者难以忍受，需要中断或终止治疗过程。已经研究了几种在光动力疗法期间控制疼痛的策略，但目前有效的方法很少。因此，本综述聚焦于光动力疗法期间疼痛强度的预测因素及疼痛管理的各个方面。
