A型肉毒杆菌毒素诱导的运动终板在周围神经修复后的作用。
The role of botulinum toxin type a-induced motor endplates after peripheral nerve repair.
作者信息
Akdeniz Zeynep D, Bayramiçli Mehmet, Ateş Filiz, Özkan Naziye, Yucesoy Can A, Ercan Feriha
机构信息
Department of Plastic, Reconstructive, and Aesthetic Surgery, Marmara University Faculty of Medicine, Fevzi Çakmak Mah, Mimar Sinan Cadde No: 41 Pendik, İstanbul, Turkey.
Department of Plastic, Reconstructive and Aesthetic Surgery, Adana Numune Training and Research Hospital, Adana, Turkey.
出版信息
Muscle Nerve. 2015 Sep;52(3):412-8. doi: 10.1002/mus.24555. Epub 2015 Jun 18.
INTRODUCTION
The aim of this study was to test the hypothesis that the increased number of new motor endplates induced by botulinum toxin type A (BTX-A) injection before nerve injury would be reinnervated after nerve repair, resulting in greater force generation.
METHODS
Thirty male Wistar rats were divided randomly into 3 groups: (1) controls; (2) a group with saline solution injection; and (3) a group with BTX-A injection into gastrocnemius muscle (BTX group). Thirty-six days after the injections the left sciatic nerve was divided and coapted in all groups. Eight weeks later, muscle forces were measured, and histological samples were collected.
RESULTS
No differences in the number of innervated endplates were found between the groups, but the number of denervated endplates was higher in the BTX group, as was the muscle tissue degeneration score. The BTX group showed distal muscle force measurements of up to 25.8% less compared with the control group.
CONCLUSION
Although BTX-A injection increases the number of motor endplates, they are not functional.
引言
本研究的目的是验证以下假设：在神经损伤前注射A型肉毒杆菌毒素（BTX-A）所诱导产生的新运动终板数量增加，在神经修复后会重新获得神经支配，从而产生更大的力量。
方法
将30只雄性Wistar大鼠随机分为3组：（1）对照组；（2）注射生理盐水组；（3）向腓肠肌注射BTX-A组（BTX组）。注射36天后，所有组均切断并接合左侧坐骨神经。8周后，测量肌肉力量并收集组织学样本。
结果
各组之间在有神经支配的终板数量上未发现差异，但BTX组中失神经支配的终板数量更多，肌肉组织退变评分也是如此。与对照组相比，BTX组的远端肌肉力量测量值降低了25.8%。
结论
虽然注射BTX-A会增加运动终板的数量，但它们并无功能。
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