Department of Plastic Reconstructive and Aesthetic Surgery, Sisli Etfal Training and Research Hospital, and Department of Neurology, Istanbul Medical Faculty, İstanbul, Turkey.
Aesthetic Plast Surg. 2012 Jun;36(3):692-7. doi: 10.1007/s00266-012-9873-6. Epub 2012 Mar 7.
Botulinum toxin prevents acetylcholine release at motor nerve terminals. Group B vitamins (B-vit) are essential for proper nerve function. The present study addresses the question of whether B-vit accelerate recovery in rat skeletal muscle after botulinum toxin A (Btx-A) injection. Forty-four adult male Wistar albino rats were used in this experimental study. Rats were divided into three groups: group 1 rats were given Btx-A injection only, group 2 rats were given B-vit supplementation before Btx-A injection, and group 3 rats were given Btx-A and B-vit injections together. During the experiment, compound muscle action potential (CMAP) of the gastrocnemius muscle was recorded before Btx-A injection and sequentially ten times after toxin injection. The statistical significance of the CMAP amplitude change among the groups was analyzed. All groups showed similar amplitude change between consecutive measurement points. In conclusion, combining Btx-A injection with B-vit supplement does not decrease the efficacy of the toxin.
肉毒毒素可阻止运动神经末梢释放乙酰胆碱。B 族维生素（B 族维生素）是神经功能正常所必需的。本研究旨在探讨 B 族维生素是否会加速肉毒毒素 A（Btx-A）注射后大鼠骨骼肌的恢复。本实验研究使用了 44 只成年雄性 Wistar 白化大鼠。将大鼠分为三组：第 1 组大鼠仅给予 Btx-A 注射，第 2 组大鼠在给予 Btx-A 注射前给予 B 族维生素补充，第 3 组大鼠同时给予 Btx-A 和 B 族维生素注射。在实验过程中，在给予 Btx-A 注射之前记录腓肠肌的复合肌肉动作电位（CMAP），并在毒素注射后连续 10 次记录。分析了各组之间 CMAP 幅度变化的统计学意义。所有组在连续测量点之间均显示出相似的幅度变化。总之，将 Btx-A 注射与 B 族维生素补充相结合不会降低毒素的疗效。
