Halkier-Sørensen L, Kragballe K, Hansen K
Department of Dermatology, Marselisborg Hospital, Aarhus, Denmark.
Acta Derm Venereol. 1989;69(2):116-9.
It is generally accepted that cutaneous Lyme borreliosis comprises erythema chronicum migrans, lymphadenosis benigna cutis, and acrodermatitis chronica atrophicans. In recent years the tick-borne spirochete Borrelia burgdorferi has been associated with a number of other cutaneous disorders. We therefore investigated sera from 175 patients with localized scleroderma (morphea) (n = 64), systemic sclerosis (n = 74), granuloma annulare (n = 16) and porphyria cutanea tarda (n = 21) with the new, highly sensitive and specific Borrelia burgdorferi flagellum ELISA assay. As controls (n = 297) served normal healthy volunteers and patients with other skin diseases. It was found that the distribution of individual antibody values and the median antibody levels were identical in controls and in patients with scleroderma, granuloma annulare and porphyria cutanea tarda. These data do not support the hypothesis of an etiological association between Borrelia burgdorferi infection and scleroderma, granuloma annulare or porphyria cutanea tarda.
一般认为，皮肤型莱姆病包括慢性游走性红斑、良性皮肤淋巴腺病和慢性萎缩性肢端皮炎。近年来，蜱传播的螺旋体伯氏疏螺旋体与许多其他皮肤疾病有关。因此，我们采用新的、高度敏感和特异的伯氏疏螺旋体鞭毛ELISA检测法，对175例局限性硬皮病（硬斑病）患者（n = 64）、系统性硬化症患者（n = 74）、环状肉芽肿患者（n = 16）和迟发性皮肤卟啉病患者（n = 21）的血清进行了检测。作为对照（n = 297）的是正常健康志愿者和患有其他皮肤病的患者。结果发现，对照组与硬皮病、环状肉芽肿和迟发性皮肤卟啉病患者的个体抗体值分布及抗体水平中位数相同。这些数据不支持伯氏疏螺旋体感染与硬皮病、环状肉芽肿或迟发性皮肤卟啉病之间存在病因学关联的假说。
