患有严重精神疾病和2型糖尿病的个体的临床特征。
Clinical characteristics of individuals with serious mental illness and type 2 diabetes.
作者信息
Sajatovic Martha, Gunzler Douglas, Einstadter Douglas, Thomas Charles, McCormick Richard A, Perzynski Adam T, Kanuch Stephanie, Cassidy Kristin A, Dawson Neal V
机构信息
Dr. Sajatovic and Ms. Cassidy are with the Department of Psychiatry, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, Ohio (e-mail:
出版信息
Psychiatr Serv. 2015 Feb 1;66(2):197-9. doi: 10.1176/appi.ps.201300538. Epub 2014 Nov 17.
OBJECTIVE
Data from 157 individuals with serious mental illness and comorbid diabetes enrolled in an ongoing treatment study were used to examine clinical correlates of diabetes control.
METHODS
Factors assessed included depressive symptoms (Montgomery-Åsberg Depression Rating Scale), global psychopathology severity (Brief Psychiatric Rating Scale), and glycosylated hemoglobin (HbA1c), a biomarker of diabetes control.
RESULTS
Seventy-seven participants had depression, 40 had schizophrenia, and 40 had bipolar disorder. Most were moderately to severely depressed with poor diabetes control. No correlation between diagnosis and diabetes control was found after adjustment for gender, race, health literacy, diabetes duration, and diabetes knowledge. Greater depression severity and longer diabetes duration were related to poorer diabetes control. Lower severity of global psychopathology was related to poorer diabetes control, perhaps because of overall low levels of psychosis and mania.
CONCLUSIONS
People with serious mental illness and diabetes face multiple challenges, which, along with severe depression, may impede diabetes self-management.
目的
对157名患有严重精神疾病且合并糖尿病并参与一项正在进行的治疗研究的个体数据进行分析，以研究糖尿病控制的临床相关因素。
方法
评估的因素包括抑郁症状（蒙哥马利-阿斯伯格抑郁评定量表）、总体精神病理学严重程度（简明精神病评定量表）以及糖化血红蛋白（HbA1c），后者是糖尿病控制的一项生物标志物。
结果
77名参与者患有抑郁症，40名患有精神分裂症，40名患有双相情感障碍。大多数人患有中度至重度抑郁症，且糖尿病控制不佳。在对性别、种族、健康素养、糖尿病病程和糖尿病知识进行调整后，未发现诊断与糖尿病控制之间存在关联。抑郁严重程度越高和糖尿病病程越长，与糖尿病控制越差有关。总体精神病理学严重程度较低与糖尿病控制较差有关，这可能是由于总体上精神病和躁狂水平较低所致。
结论
患有严重精神疾病和糖尿病的人面临多重挑战，这些挑战连同严重抑郁症可能会妨碍糖尿病自我管理。
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