从想法到疗效：用于开发慢性病行为治疗方法的ORBIT模型。
From ideas to efficacy: The ORBIT model for developing behavioral treatments for chronic diseases.
作者信息
Czajkowski Susan M, Powell Lynda H, Adler Nancy, Naar-King Sylvie, Reynolds Kim D, Hunter Christine M, Laraia Barbara, Olster Deborah H, Perna Frank M, Peterson Janey C, Epel Elissa, Boyington Josephine E, Charlson Mary E
机构信息
Clinical Applications and Prevention Branch, Division of Cardiovascular Sciences, National Heart, Lung, and Blood Institute, National Institutes of Health.
Department of Preventive Medicine, Rush University Medical Center.
出版信息
Health Psychol. 2015 Oct;34(10):971-82. doi: 10.1037/hea0000161. Epub 2015 Feb 2.
OBJECTIVE
Given the critical role of behavior in preventing and treating chronic diseases, it is important to accelerate the development of behavioral treatments that can improve chronic disease prevention and outcomes. Findings from basic behavioral and social sciences research hold great promise for addressing behaviorally based clinical health problems, yet there is currently no established pathway for translating fundamental behavioral science discoveries into health-related treatments ready for Phase III efficacy testing. This article provides a systematic framework for developing behavioral treatments for preventing and treating chronic diseases.
METHOD
The Obesity-Related Behavioral Intervention Trials (ORBIT) model for behavioral treatment development features a flexible and progressive process, prespecified clinically significant milestones for forward movement, and return to earlier stages for refinement and optimization.
RESULTS
This article presents the background and rationale for the ORBIT model, a summary of key questions for each phase, a selection of study designs and methodologies well-suited to answering these questions, and prespecified milestones for forward or backward movement across phases.
CONCLUSIONS
The ORBIT model provides a progressive, clinically relevant approach to increasing the number of evidence-based behavioral treatments available to prevent and treat chronic diseases. (PsycINFO Database Record
目的
鉴于行为在预防和治疗慢性病中起着关键作用，加快开发能够改善慢性病预防和治疗效果的行为治疗方法非常重要。基础行为科学和社会科学研究的结果对于解决基于行为的临床健康问题具有很大的前景，但目前尚无将基础行为科学发现转化为可进行III期疗效测试的健康相关治疗方法的既定途径。本文提供了一个用于开发预防和治疗慢性病的行为治疗方法的系统框架。
方法
用于行为治疗开发的肥胖相关行为干预试验（ORBIT）模型具有灵活且渐进的过程、预先设定的具有临床意义的向前推进的里程碑，以及返回早期阶段进行完善和优化的机制。
结果
本文介绍了ORBIT模型的背景和原理、每个阶段的关键问题总结、一系列适合回答这些问题的研究设计和方法，以及跨阶段向前或向后推进的预先设定的里程碑。
结论
ORBIT模型提供了一种渐进的、与临床相关的方法，以增加可用于预防和治疗慢性病的循证行为治疗方法的数量。（PsycINFO数据库记录）
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