Guo Jimmy, Widgerow Alan D, Banyard Derek, Toranto Jason, Wirth Garrett A, Paydar Keyianoosh, Tocco-Tussardi Ilaria, Evans Gregory R D
From the Department of Plastic Surgery, Center for Tissue Engineering, University of California, Irvine, Orange, CA.
Ann Plast Surg. 2015 Mar;74(3):376-82. doi: 10.1097/SAP.0000000000000416.
Although lipotransfer, or fat grafting, is a commonly used procedure in aesthetic and reconstructive surgery, there is still variability in graft survival and neoadipogenesis from one procedure to the next. A better understanding of the sequential molecular events occurring with grafting would allow us to strategize methods to improve the regenerative potency of the grafted tissue. These steps begin with an autophagic process, followed by the inclusion of stromal vascular fraction and matrix components. By tailoring and modifying each of these steps for a particular type of aesthetic or reconstructive procedure, strategic sequencing represents a dynamic approach to lipotransfer with the aim of maximizing adipocyte viability and growth. In the implementation of the strategic sequence, it remains important to consider the clinical viability of each step and its compliance with the US Food and Drug Administration regulations. This review highlights the basic science behind clinically translatable approaches to supplementing various fat grafting procedures.
尽管脂肪移植，即脂肪填充，是美容整形手术中常用的一种手术方法，但每次手术的移植存活率和新脂肪生成仍存在差异。更好地了解移植过程中发生的一系列分子事件，将有助于我们制定策略，以提高移植组织的再生能力。这些步骤始于自噬过程，随后包含基质血管成分和基质成分。通过针对特定类型的美容或整形手术调整和修改这些步骤中的每一步，策略性排序代表了一种动态的脂肪移植方法，旨在最大限度地提高脂肪细胞的活力和生长。在实施策略性排序时，考虑每个步骤的临床可行性及其是否符合美国食品药品监督管理局的规定仍然很重要。本综述强调了补充各种脂肪移植手术的临床可转化方法背后的基础科学。
