Nano Electronic Center of Excellence, Thin Film and Nanoelectronic Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran; Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran.
Nano Electronic Center of Excellence, Thin Film and Nanoelectronic Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran; Nano Electronic Center of Excellence, Nano Bio Electronic Devices Lab, School of Electrical and Computer Eng, University of Tehran, Tehran, Iran, P.O. Box 14395/515, Tehran, Iran.
Biosens Bioelectron. 2015 Jun 15;68:577-585. doi: 10.1016/j.bios.2015.01.057. Epub 2015 Jan 24.
We developed a silicon nanowire based electrical cell impedance sensor (SiNW-ECIS) as an instrument that detects cancerous cultured living lung cells by monitoring their spreading state at which the cells stretched and become extended on nanowires. Further current penetration into the extended membrane of malignant cells in respect to normal ones (In the first 6h after cells interaction with surface) are the key mechanism in our diagnosis procedure. The developed device applied to monitor the spreading-induced electrical differences between cancerous and normal lung cells in an integral fashion. Detection was performed so faster than the time required to complete cells mitosis. Morphology and architecture of doped Si nanowires covered microelectrodes observably enhance the contact area between cells and electrodes which support accurate signal recording from stretched cells as indicated by SEM and florescent images.
我们开发了一种基于硅纳米线的电细胞阻抗传感器（SiNW-ECIS），作为一种通过监测癌细胞在纳米线上伸展和扩展的扩散状态来检测癌细胞的仪器。进一步将电流穿透到恶性细胞的扩展膜中，相对于正常细胞而言（在细胞与表面相互作用后的前 6 小时内），这是我们诊断程序中的关键机制。所开发的设备用于以整体方式监测癌细胞和正常肺细胞之间的扩散诱导的电差异。检测速度比细胞有丝分裂所需的时间更快。掺杂硅纳米线覆盖微电极的形态和结构明显增加了细胞与电极之间的接触面积，这支持了从伸展细胞中进行准确信号记录，这一点通过 SEM 和荧光图像得到了证实。
