在印度尼西亚摩鹿加裸背果蝠中检测到冠状病毒基因组。
Detection of coronavirus genomes in Moluccan naked-backed fruit bats in Indonesia.
作者信息
Anindita Paulina Duhita, Sasaki Michihito, Setiyono Agus, Handharyani Ekowati, Orba Yasuko, Kobayashi Shintaro, Rahmadani Ibnu, Taha Siswatiana, Adiani Sri, Subangkit Mawar, Nakamura Ichiro, Sawa Hirofumi, Kimura Takashi
机构信息
Division of Molecular Pathobiology, Research Center for Zoonosis Control, Hokkaido University, North 20 West 10, Kita-ku, Sapporo, 001-0020, Japan.
出版信息
Arch Virol. 2015 Apr;160(4):1113-8. doi: 10.1007/s00705-015-2342-1. Epub 2015 Feb 4.
Bats have been shown to serve as natural reservoirs for numerous emerging viruses including severe acute respiratory syndrome coronavirus (SARS-CoV). In the present study, we report the discovery of bat CoV genes in Indonesian Moluccan naked-backed fruit bats (Dobsonia moluccensis). A partial RNA-dependent RNA polymerase gene sequence was detected in feces and tissues samples from the fruit bats, and the region between the RdRp and helicase genes could also be amplified from fecal samples. Phylogenetic analysis suggested that these bat CoVs are related to members of the genus Betacoronavirus.
蝙蝠已被证明是包括严重急性呼吸综合征冠状病毒（SARS-CoV）在内的多种新兴病毒的天然宿主。在本研究中，我们报告了在印度尼西亚摩鹿加裸背果蝠（Dobsonia moluccensis）中发现蝙蝠冠状病毒基因。在果蝠的粪便和组织样本中检测到了部分依赖RNA的RNA聚合酶基因序列，并且还能从粪便样本中扩增出RdRp和解旋酶基因之间的区域。系统发育分析表明，这些蝙蝠冠状病毒与β冠状病毒属的成员有关。
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