富含异黄酮的大豆蛋白预防小鼠维甲酸诱导的骨质疏松症。
Prevention of retinoic acid-induced osteoporosis in mice by isoflavone-enriched soy protein.
作者信息
Yang Juan, Wu Nana, Peng Jie, Yang Xiaoquan, Guo Jian, Yin Shouwei, Wang Jinmei
机构信息
Research and Development Center of Food Proteins, Department of Food Science and Technology, South China University of Technology (SCUT), Guangzhou 510640, P.R. China.
Academy of State Administration of Grain, Beijing 100037, P.R. China.
出版信息
J Sci Food Agric. 2016 Jan 15;96(1):331-8. doi: 10.1002/jsfa.7098. Epub 2015 Feb 16.
BACKGROUND
A novel soy protein aggregate enriched with isoflavones (SPA-IS), a mixture of soy protein and isoflavones (Mix), isoflavones (IS), and the soy protein were obtained to investigate the preventive effects on osteoporosis induced by retinoic acid in Kunming mice.
RESULTS
The serum osteocalcin levels in the Mix and SPA-IS groups decreased compared with the model group (mice showing retinoic acid-induced osteoporosis) (P < 0.05). The trabecular analysis results showed an increased preventive effect of the SPA-IS group over the Mix group, the IS group, and the soy protein group. The results of both left tibial maximum load and the 4th lumbar structural strength differ between the IS and the SPA-IS groups.
CONCLUSION
The SPA-IS exhibited obvious oestrogenic activities on retinoic acid-induced osteoporosis in Kunming mice compared to Mix, IS, and soy protein. The results suggest that there is a potential use for SPA-IS in the treatment of osteoporosis induced by intake of retinoic acid. The improvement of bone indicators might be attributed to the formation of aggregate particles and the improvement of IS solubility.
背景
获得了一种富含异黄酮的新型大豆蛋白聚集体（SPA-IS）、大豆蛋白与异黄酮的混合物（Mix）、异黄酮（IS）和大豆蛋白，以研究它们对昆明小鼠维甲酸诱导骨质疏松症的预防作用。
结果
与模型组（显示维甲酸诱导骨质疏松症的小鼠）相比，Mix组和SPA-IS组的血清骨钙素水平降低（P<0.05）。小梁分析结果表明，SPA-IS组比Mix组、IS组和大豆蛋白组具有更强的预防作用。IS组和SPA-IS组的左胫骨最大负荷和第4腰椎结构强度结果不同。
结论
与Mix、IS和大豆蛋白相比，SPA-IS对昆明小鼠维甲酸诱导的骨质疏松症表现出明显的雌激素活性。结果表明，SPA-IS在治疗维甲酸摄入引起的骨质疏松症方面具有潜在用途。骨指标的改善可能归因于聚集颗粒的形成和IS溶解度的提高。
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