Desai K, Mistry P, Bagget C, Burroughs A K, Bellamy M F, Owen J S
Academic Department of Medicine, Royal Free Hospital School of Medicine, London.
Lancet. 1989 Apr 1;1(8640):693-5. doi: 10.1016/s0140-6736(89)92207-1.
ADP-induced aggregation of normal washed platelets was measured by nephelometry in the presence of plasma high density lipoprotein (HDL) from normal subjects and from 30 patients with hepatic cirrhosis. HDL, at one-eighth of its plasma concentration, inhibited platelet aggregation; the effect of cirrhotic HDL (40% [SD 29%] inhibition) was significantly greater than that of normal HDL (16% [11%]). The mean apolipoprotein E content of cirrhotic HDL was significantly higher than that of normal HDL, and strongly inhibitory HDL contained twice as many apolipoprotein-E-rich particles as weakly inhibitory HDL. Inhibition of platelet aggregation was correlated with the apolipoprotein E content of HDL from patients with cirrhosis.
采用比浊法在存在正常受试者及30例肝硬化患者血浆高密度脂蛋白（HDL）的情况下，测定二磷酸腺苷（ADP）诱导的正常洗涤血小板的聚集情况。HDL在其血浆浓度的八分之一时可抑制血小板聚集；肝硬化患者的HDL（抑制率40%[标准差29%]）的作用明显强于正常HDL（抑制率16%[11%]）。肝硬化患者HDL的载脂蛋白E平均含量明显高于正常HDL，强抑制性HDL中富含载脂蛋白E的颗粒数量是弱抑制性HDL的两倍。肝硬化患者HDL对血小板聚集的抑制作用与载脂蛋白E含量相关。
