Pailee Phanruethai, Prachyawarakorn Vilailak, Ruchirawat Somsak, Mahidol Chulabhorn
Laboratory of Natural Products, Chulabhorn Research Institute, Kamphang Phet 6 Road, Bangkok 10210 (Thailand).
Chem Asian J. 2015 Apr;10(4):910-4. doi: 10.1002/asia.201403253. Epub 2015 Feb 2.
A dichloromethane extract of the stems of Alangium salviifolium afforded twelve cardinane sesquiterpenes, seven of which are new alangenes A-G (1-7) and five known compounds (8-12). Their structures were elucidated on the basis of spectroscopic techniques including UV, IR, and NMR spectroscopies, and mass spectrometry. Most of the tested compounds exhibited very potent aromatase inhibition properties, especially in the case of the cardinane sesquiterpenes 1, 5-8, and 10 (IC50 values of 0.09, 0.13, 0.30, 0.06, 2.05, and 1.19 μM, respectively), which are significantly better than that of the positive control (ketoconazole, IC50 of 2.4 μM). Compounds 1 and 4 exhibited selective cytotoxicity against the MOLT-3 cancer cell line with IC50 values of 7.9 and 2.1 μg mL(-1) , respectively.
柳杉叶八角枫茎的二氯甲烷提取物得到了12种蒈烷型倍半萜，其中7种是新的柳杉烯A - G（1 - 7），还有5种已知化合物（8 - 12）。它们的结构是基于紫外光谱、红外光谱、核磁共振光谱和质谱等光谱技术确定的。大多数测试化合物表现出非常强的芳香酶抑制特性，尤其是蒈烷型倍半萜1、5 - 8和10（IC50值分别为0.09、0.13、0.30、0.06、2.05和1.19 μM），明显优于阳性对照（酮康唑，IC50为2.4 μM）。化合物1和4对MOLT - 3癌细胞系表现出选择性细胞毒性，IC50值分别为7.9和2.1 μg mL(-1)。
