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肥胖青少年摄入果糖后酰基胃饥饿素抑制反应减弱：胰岛素抵抗的作用。

Blunted suppression of acyl-ghrelin in response to fructose ingestion in obese adolescents: the role of insulin resistance.

作者信息

Van Name Michelle, Giannini Cosimo, Santoro Nicola, Jastreboff Ania M, Kubat Jessica, Li Fangyong, Kursawe Romy, Savoye Mary, Duran Elvira, Dziura James, Sinha Rajita, Sherwin Robert S, Cline Gary, Caprio Sonia

机构信息

Department of Pediatrics, Division of Pediatric Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA.

出版信息

Obesity (Silver Spring). 2015 Mar;23(3):653-61. doi: 10.1002/oby.21019. Epub 2015 Feb 3.

DOI:10.1002/oby.21019
PMID:25645909
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4548801/
Abstract

OBJECTIVE

Fructose consumption has risen alongside obesity and diabetes. Gut hormones involved in hunger and satiety (ghrelin and PYY) may respond differently to fructose compared with glucose ingestion. This study evaluated the effects of glucose and fructose ingestion on ghrelin and PYY in lean and obese adolescents with differing insulin sensitivity.

METHODS

Adolescents were divided into lean (n = 14), obese insulin sensitive (n = 12) (OIS), and obese insulin resistant (n = 15) (OIR). In a double-blind, cross-over design, subjects drank 75 g of glucose or fructose in random order, serum was obtained every 10 minutes for 60 minutes.

RESULTS

Baseline acyl-ghrelin was highest in lean and lowest in OIR (P = 0.02). After glucose ingestion, acyl-ghrelin decreased similarly in lean and OIS but was lower in OIR (vs. lean, P = 0.03). Suppression differences were more pronounced after fructose (lean vs. OIS, P = 0.008, lean vs. OIR, P < 0.001). OIS became significantly hungrier after fructose (P = 0.015). PYY was not significantly different at baseline, varied minimally after glucose, and rose after fructose.

CONCLUSIONS

Compared with lean, OIS adolescents have impaired acyl-ghrelin responses to fructose but not glucose, whereas OIR adolescents have blunted responses to both. Diminished suppression of acyl-ghrelin in childhood obesity, particularly if accompanied by insulin resistance, may promote hunger and overeating.

摘要

目的

果糖摄入量随着肥胖和糖尿病的增加而上升。与饥饿和饱腹感相关的肠道激素（胃饥饿素和肽YY）对果糖的反应可能与摄入葡萄糖时不同。本研究评估了葡萄糖和果糖摄入对胰岛素敏感性不同的瘦和肥胖青少年胃饥饿素和肽YY的影响。

方法

青少年被分为瘦组（n = 14）、肥胖胰岛素敏感组（n = 12）（OIS）和肥胖胰岛素抵抗组（n = 15）（OIR）。在双盲、交叉设计中，受试者随机顺序饮用75克葡萄糖或果糖，在60分钟内每10分钟采集一次血清。

结果

基线酰基胃饥饿素水平在瘦组中最高，在OIR组中最低（P = 0.02）。摄入葡萄糖后，酰基胃饥饿素在瘦组和OIS组中下降情况相似，但在OIR组中较低（与瘦组相比，P = 0.03）。果糖摄入后抑制差异更明显（瘦组与OIS组，P = 0.008，瘦组与OIR组，P < 0.001）。OIS组在摄入果糖后饥饿感显著增加（P = 0.015）。肽YY在基线时无显著差异，摄入葡萄糖后变化最小，摄入果糖后升高。

结论

与瘦青少年相比，OIS青少年对果糖而非葡萄糖的酰基胃饥饿素反应受损，而OIR青少年对两者的反应均减弱。儿童肥胖时酰基胃饥饿素抑制减弱，特别是伴有胰岛素抵抗时，可能会促进饥饿和暴饮暴食。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8247/4548801/dceda96c47c7/nihms650004f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8247/4548801/e014afb1e213/nihms650004f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8247/4548801/a52c5f8e0a68/nihms650004f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8247/4548801/413ee09649bb/nihms650004f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8247/4548801/6fa263be10ed/nihms650004f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8247/4548801/dceda96c47c7/nihms650004f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8247/4548801/e014afb1e213/nihms650004f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8247/4548801/a52c5f8e0a68/nihms650004f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8247/4548801/413ee09649bb/nihms650004f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8247/4548801/6fa263be10ed/nihms650004f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8247/4548801/dceda96c47c7/nihms650004f5.jpg

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