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除了线粒体,细胞的能量来源还会是什么呢?

Beyond mitochondria, what would be the energy source of the cell?

作者信息

Herrera Arturo S, Del C A Esparza Maria, Md Ashraf Ghulam, Zamyatnin Andrey A, Aliev Gjumrakch

机构信息

"GALLY" International Biomedical Research Institute Inc., 7733 Louis Pasteur Drive, #330, San Antonio, TX, 78229 USA.

出版信息

Cent Nerv Syst Agents Med Chem. 2015;15(1):32-41. doi: 10.2174/1871524915666150203093656.

Abstract

Currently, cell biology is based on glucose as the main source of energy. Cellular bioenergetic pathways have become unnecessarily complex in their eagerness to explain that how the cell is able to generate and use energy from the oxidation of glucose, where mitochondria play an important role through oxidative phosphorylation. During a descriptive study about the three leading causes of blindness in the world, the ability of melanin to transform light energy into chemical energy through the dissociation of water molecule was unraveled. Initially, during 2 or 3 years; we tried to link together our findings with the widely accepted metabolic pathways already described in metabolic pathway databases, which have been developed to collect and organize the current knowledge on metabolism scattered across a multitude of scientific articles. However, firstly, the literature on metabolism is extensive but rarely conclusive evidence is available, and secondly, one would expect these databases to contain largely the same information, but the contrary is true. For the apparently well studied metabolic process Krebs cycle, which was described as early as 1937 and is found in nearly every biology and chemistry curriculum, there is a considerable disagreement between at least five databases. Of the nearly 7000 reactions contained jointly by these five databases, only 199 are described in the same way in all the five databases. Thus to try to integrate chemical energy from melanin with the supposedly well-known bioenergetic pathways is easier said than done; and the lack of consensus about metabolic network constitutes an insurmountable barrier. After years of unsuccessful results, we finally realized that the chemical energy released through the dissociation of water molecule by melanin represents over 90% of cell energy requirements. These findings reveal a new aspect of cell biology, as glucose and ATP have biological functions related mainly to biomass and not so much with energy. Our finding about the unexpected intrinsic property of melanin to transform photon energy into chemical energy through the dissociation of water molecule, a role performed supposedly only by chlorophyll in plants, seriously questions the sacrosanct role of glucose and thereby mitochondria as the primary source of energy and power for the cells.

摘要

目前,细胞生物学以葡萄糖作为主要能量来源。细胞生物能量代谢途径在急于解释细胞如何从葡萄糖氧化中产生和利用能量时变得不必要地复杂,其中线粒体通过氧化磷酸化发挥重要作用。在一项关于全球三大主要致盲原因的描述性研究中,发现了黑色素通过水分子解离将光能转化为化学能的能力。最初,在两到三年的时间里,我们试图将我们的发现与代谢途径数据库中已被广泛接受的代谢途径联系起来,这些数据库是为收集和整理分散在众多科学文章中的当前代谢知识而开发的。然而,首先,关于代谢的文献广泛,但很少有确凿的证据,其次,人们原本期望这些数据库包含大致相同的信息,但事实恰恰相反。对于早在1937年就被描述且几乎在每一门生物学和化学课程中都能找到的、看似研究充分的代谢过程—— Krebs循环,至少五个数据库之间存在相当大的分歧。在这五个数据库共同包含的近7000个反应中,只有199个在所有五个数据库中的描述方式相同。因此,试图将来自黑色素的化学能与本应广为人知的生物能量代谢途径整合起来,说起来容易做起来难;而且代谢网络缺乏共识构成了一个无法逾越的障碍。经过多年无果的研究,我们最终意识到,黑色素通过水分子解离释放的化学能占细胞能量需求的90%以上。这些发现揭示了细胞生物学的一个新方面,因为葡萄糖和ATP的生物学功能主要与生物量相关,而与能量关系不大。我们关于黑色素通过水分子解离将光子能量转化为化学能这一意外内在特性的发现,而这一作用通常被认为只有植物中的叶绿素才能完成,这严重质疑了葡萄糖以及线粒体作为细胞主要能量和动力来源的神圣地位。

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