Hussein Ahmed A, Adams Austin S, Turner Justin H
Department of Otolaryngology-Head and Neck Surgery, Cairo University School of Medicine, Cairo, Egypt.
Department of Otolaryngology-Head and Neck Surgery, Vanderbilt University School of Medicine, Nashville, Tennessee, U.S.A.
Laryngoscope. 2015 Sep;125(9):2193-8. doi: 10.1002/lary.25168. Epub 2015 Feb 3.
Patulous Eustachian tube (PET) is a challenging clinical problem with limited medical and surgical options. The current study systematically reviews the literature to determine the safety and efficacy of surgical treatments for PET.
Medline, Google Scholar, and Cochrane databases.
Studies evaluating the surgical management of PET were extracted based on defined inclusion criteria. Data including surgical techniques, outcomes, and complications were extracted and analyzed.
A total of 1,616 studies were retrieved from the initial search. Of these, 14 studies comprising a total of 226 patients (253 sides) met inclusion criteria and were evaluated for surgical techniques, patient outcomes, and complications. As defined by the Oxford Center for Evidence-Based Medicine (Oxford, UK), all studies were classified as level 4 evidence. The most commonly reported techniques were ET plugging (3 studies), PE tube placement (2 studies), and suture ligation (2 studies). Postoperative follow-up ranged from 2 to 60 months (mean, 20.6 months). Outcome measures varied significantly between individual studies, with overall symptom improvement reported between 22% and 100% (mean 72.4%; 95% CI, 62.5%-81.2%). A low incidence of minor complications was reported in nine of 14 studies.
Current literature evaluating the surgical management of PET is limited and comprised entirely of level 4 studies. Comparisons between techniques were not possible due to the small number of studies and variable outcome measures. Future larger studies evaluating defined outcomes and quality-of-life measures are needed to determine the comparative efficacy of surgical treatments for this challenging condition.
咽鼓管异常开放(PET)是一个具有挑战性的临床问题,药物和手术治疗选择有限。本研究系统回顾文献,以确定PET手术治疗的安全性和有效性。
医学文献数据库、谷歌学术和考克兰数据库。
根据既定的纳入标准提取评估PET手术治疗的研究。提取并分析包括手术技术、结果和并发症在内的数据。
初步检索共获得1616项研究。其中,14项研究共纳入226例患者(253侧),符合纳入标准,并对手术技术、患者结果和并发症进行了评估。根据英国牛津循证医学中心的定义,所有研究均归类为4级证据。最常报道的技术是咽鼓管堵塞(3项研究)、咽鼓管置管(2项研究)和缝合结扎(2项研究)。术后随访时间为2至60个月(平均20.6个月)。各研究之间的结果测量差异很大,总体症状改善率在22%至100%之间(平均72.4%;95%CI,62.5%-81.2%)。14项研究中有9项报道了轻微并发症的发生率较低。
目前评估PET手术治疗的文献有限,且完全由4级研究组成。由于研究数量少和结果测量方法多样,无法对不同技术进行比较。未来需要开展更大规模的研究,评估明确的结果和生活质量指标,以确定针对这一具有挑战性病症的手术治疗的相对疗效。