Moseley Brian D, DeGiorgio Christopher M
Department of Neurology and Rehabilitation Medicine, University of Cincinnati, Cincinnati, OH, USA.
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA.
Epilepsy Res. 2015 Nov;117:82-4. doi: 10.1016/j.eplepsyres.2015.09.006. Epub 2015 Sep 9.
To help identify patients at greatest risk for sudden unexpected death in epilepsy (SUDEP), screening inventories like the SUDEP-7 Inventory can be useful. In this study, we examined the strength of association between this inventory's risk factors and postictal generalized EEG suppression (PGES), a biomarker of SUDEP risk. We reanalyzed data from an epilepsy monitoring unit study of 37 children. We performed a 2 by 2 contingency table analysis to determine the association between "yes" responses on the inventory questions and PGES following >=1 seizure. Having a history of >3 generalized tonic-clonic seizures (GTCS) in the past year had the strongest association with PGES (Pearson chi-square p<0.001, Cramer's V=0.75). Having >=1 GTCS in the past year was also strongly associated with PGES (Pearson chi-square p<0.001, Cramer's V=0.636). Histories of >50 seizures of any type/month (Pearson chi-square p=0.14, Cramer's V=0.241) and intellectual disability (Pearson chi-square p=0.04, Cramer's V=0.337) were not as robustly associated with PGES. Current use of >=3 AEDs had the weakest association with PGES (Pearson chi-square p=0.66, Cramer's V=0.072). Given that all study patients had >=1 seizure per year and epilepsy durations <30 years, the strength of association with these questions and PGES could not be analyzed.
为了帮助识别癫痫患者中发生癫痫性猝死（SUDEP）风险最高的患者，像SUDEP-7量表这样的筛查量表可能会有所帮助。在本研究中，我们检验了该量表的风险因素与发作后广泛性脑电图抑制（PGES）之间的关联强度，PGES是SUDEP风险的一个生物标志物。我们重新分析了一项针对37名儿童的癫痫监测单元研究的数据。我们进行了2×2列联表分析，以确定量表问题上的“是”回答与≥1次发作后的PGES之间的关联。过去一年有>3次全面性强直阵挛发作（GTCS）病史与PGES的关联最强（Pearson卡方检验p<0.001，Cramer's V=0.75）。过去一年有≥1次GTCS也与PGES密切相关（Pearson卡方检验p<0.001，Cramer's V=0.636）。每月发作>50次任何类型癫痫的病史（Pearson卡方检验p=0.14，Cramer's V=0.241）和智力残疾（Pearson卡方检验p=0.04，Cramer's V=0.337）与PGES的关联不那么显著。目前使用≥3种抗癫痫药物（AEDs）与PGES的关联最弱（Pearson卡方检验p=0.66，Cramer's V=0.072）。鉴于所有研究患者每年至少发作≥1次且癫痫病程<30年，无法分析这些问题与PGES的关联强度。
