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静脉注射劳拉西泮能预防发作后广泛性脑电图抑制吗?一例病例报告。

Can intravenous lorazepam prevent postictal generalized EEG suppression? A case report.

作者信息

Ramilevich Zack, Zarroli Katherine

机构信息

University of Florida, Jacksonville, FL, USA.

出版信息

Clin Neurophysiol Pract. 2024 Jun 20;9:201-204. doi: 10.1016/j.cnp.2024.06.002. eCollection 2024.

DOI:10.1016/j.cnp.2024.06.002
PMID:39055311
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11269814/
Abstract

BACKGROUND

Postictal generalized electrographic suppression (PGES) may be considered an electrophysiological marker associated with an increased risk of sudden unexplained death in epilepsy (SUDEP).

CASE PRESENTATION

A case study is presented whereby a young man with focal to bilateral tonic-clonic seizures exhibited PGES after two spontaneously-aborted seizures; yet, after a third benzodiazepine-aborted seizure, PGES was absent.

CONCLUSION

This suggests that acutely administered benzodiazepines may offer direct anti-suppressive effects to prevent PGES, potentially reducing SUDEP risk.

摘要

背景

发作后广泛性脑电图抑制(PGES)可能被视为与癫痫性不明原因猝死(SUDEP)风险增加相关的一种电生理标志物。

病例报告

本文介绍了一项病例研究,一名患有局灶性至双侧强直阵挛性发作的年轻男子在两次自行终止的发作后出现了PGES;然而,在第三次使用苯二氮䓬类药物终止的发作后,PGES消失了。

结论

这表明急性给予苯二氮䓬类药物可能具有直接的抗抑制作用,以预防PGES,从而可能降低SUDEP风险。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/11269814/03fbd0c7d3fb/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/11269814/5291c6a728c1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/11269814/003db798b54b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/11269814/03fbd0c7d3fb/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/11269814/5291c6a728c1/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/11269814/003db798b54b/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0535/11269814/03fbd0c7d3fb/gr3.jpg

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本文引用的文献

1
The association of serotonin reuptake inhibitors and benzodiazepines with ictal central apnea.SSRIs 和苯二氮䓬类药物与发作性中枢性睡眠呼吸暂停的关联。
Epilepsy Behav. 2019 Sep;98(Pt A):73-79. doi: 10.1016/j.yebeh.2019.06.029. Epub 2019 Jul 10.
2
Impaired CO-Induced Arousal in SIDS and SUDEP.CO 诱导觉醒障碍与 SIDS 和 SUDEP。
Trends Neurosci. 2019 Apr;42(4):242-250. doi: 10.1016/j.tins.2019.02.002.
3
Postictal generalized EEG suppression and SUDEP: a review.发作后广泛性脑电图抑制与癫痫性猝死:综述
J Clin Neurophysiol. 2015 Feb;32(1):14-20. doi: 10.1097/WNP.0000000000000147.
4
Specific deletion of NaV1.1 sodium channels in inhibitory interneurons causes seizures and premature death in a mouse model of Dravet syndrome.抑制性中间神经元中钠通道 Nav1.1 的特异性缺失导致 Dravet 综合征小鼠模型发生癫痫发作和过早死亡。
Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14646-51. doi: 10.1073/pnas.1211591109. Epub 2012 Aug 20.
5
An electroclinical case-control study of sudden unexpected death in epilepsy.癫痫相关性猝死的电临床病例对照研究。
Ann Neurol. 2010 Dec;68(6):787-96. doi: 10.1002/ana.22101.