Ramilevich Zack, Zarroli Katherine
University of Florida, Jacksonville, FL, USA.
Clin Neurophysiol Pract. 2024 Jun 20;9:201-204. doi: 10.1016/j.cnp.2024.06.002. eCollection 2024.
Postictal generalized electrographic suppression (PGES) may be considered an electrophysiological marker associated with an increased risk of sudden unexplained death in epilepsy (SUDEP).
A case study is presented whereby a young man with focal to bilateral tonic-clonic seizures exhibited PGES after two spontaneously-aborted seizures; yet, after a third benzodiazepine-aborted seizure, PGES was absent.
This suggests that acutely administered benzodiazepines may offer direct anti-suppressive effects to prevent PGES, potentially reducing SUDEP risk.
发作后广泛性脑电图抑制(PGES)可能被视为与癫痫性不明原因猝死(SUDEP)风险增加相关的一种电生理标志物。
本文介绍了一项病例研究,一名患有局灶性至双侧强直阵挛性发作的年轻男子在两次自行终止的发作后出现了PGES;然而,在第三次使用苯二氮䓬类药物终止的发作后,PGES消失了。
这表明急性给予苯二氮䓬类药物可能具有直接的抗抑制作用,以预防PGES,从而可能降低SUDEP风险。