甲状腺功能障碍对骨代谢的影响。
The influence of thyroid dysfunction on bone metabolism.
作者信息
Tuchendler Dominika, Bolanowski Marek
机构信息
Endocrinology Department, Clinic of Internal Medicine, 4th Military Hospital, Wrocław, Poland.
Chair and Department of Endocrinology, Diabetes and Isotope Therapy, Medical University Wrocław, Wrocław, Poland.
出版信息
Thyroid Res. 2014 Dec 20;7(1):12. doi: 10.1186/s13044-014-0012-0. eCollection 2014.
Abstract
Loss of bone mineral density due to osteoporosis is the main cause of fragility fractures and leads to dropped quality of life and increased mortality. Disturbance of balance between bone formation and bone resorption is dangerous, can cause loss of bone mass and disruption of it's architecture. Correct development, achievement of peak bone mass and normal functioning of human skeleton depend on different factors. The pivotal role in bone metabolism play thyroid hormones. Both excess as well as deficiency of fT4 and fT3 can be potentially deleterious for bone tissue. The aim of this study is to review the current literature concerning the role of thyroid hormones on bone metabolism.
摘要
骨质疏松导致的骨矿物质密度丧失是脆性骨折的主要原因，会导致生活质量下降和死亡率增加。骨形成与骨吸收之间的平衡紊乱很危险，会导致骨量流失及其结构破坏。人类骨骼的正常发育、达到峰值骨量以及正常功能取决于不同因素。甲状腺激素在骨代谢中起关键作用。游离甲状腺素（fT4）和游离三碘甲状腺原氨酸（fT3）过多或过少都可能对骨组织产生潜在危害。本研究的目的是综述当前有关甲状腺激素在骨代谢中作用的文献。
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