Combe Colin W, Fischer Lutz, Rappsilber Juri
From the ‡Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom;
From the ‡Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, United Kingdom; §Department of Bioanalytics, Institute of Biotechnology, Technische Universität Berlin, 13355 Berlin, Germany
Mol Cell Proteomics. 2015 Apr;14(4):1137-47. doi: 10.1074/mcp.O114.042259. Epub 2015 Feb 3.
xiNET is a visualization tool for exploring cross-linking/mass spectrometry results. The interactive maps of the cross-link network that it generates are a type of node-link diagram. In these maps xiNET displays: (1) residue resolution positional information including linkage sites and linked peptides; (2) all types of cross-linking reaction product; (3) ambiguous results; and, (4) additional sequence information such as domains. xiNET runs in a browser and exports vector graphics which can be edited in common drawing packages to create publication quality figures.
xiNET is open source, released under the Apache version 2 license. Results can be viewed by uploading data to http://crosslinkviewer.org/ or by downloading the software from http://github.com/colin-combe/crosslink-viewer and running it locally.
xiNET是一种用于探索交联/质谱结果的可视化工具。它生成的交联网络交互式图谱是一种节点-链接图。在这些图谱中，xiNET显示：(1) 残基分辨率位置信息，包括连接位点和连接的肽段；(2) 所有类型的交联反应产物；(3) 模糊结果；以及(4) 其他序列信息，如结构域。xiNET在浏览器中运行，并导出矢量图形，这些图形可在常见绘图软件包中编辑以创建具有出版质量的图表。
xiNET是开源的，根据Apache 2.0版本许可发布。可以通过将数据上传到http://crosslinkviewer.org/ 或从http://github.com/colin-combe/crosslink-viewer下载软件并在本地运行来查看结果。
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