Shenton M E, Ballinger R, Marcy B, Faux S F, Cane M, Lemay M, Cassens G, Coleman M, Duffy F H, McCarley R W
Department of Psychiatry (VAMC-Brockton and MMHC), Harvard Medical School, Massachusetts.
J Nerv Ment Dis. 1989 Apr;177(4):219-25. doi: 10.1097/00005053-198904000-00005.
In four schizophrenic patients, we examined the relationship between clinical course, including neuroleptic response, and the following biological and psychological measures: topography of the auditory P300 event-related potential, computerized tomography (CT), Andreasen's positive and negative symptom scales, the Thought Disorder Index, and a neuropsychological test battery. Two previous studies in our laboratory had shown that schizophrenic patients were differentiated from a matched normal control group by a left temporal scalp region deficit in P300 topography. This present report compares two schizophrenic patients with the typical left temporal P300 topography deficit with two schizophrenic patients with a right temporal P300 topography deficit. The two right temporal deficit patients had more positive symptoms, more thought disorder, more severely impaired functioning, earlier age of onset, poorer response to neuroleptic medications, more diffuse cognitive deficits on a neuropsychological testing battery, and poorer premorbid history than the two left temporal deficit patients. There was some evidence for the presence of more CT abnormalities suggestive of frontal lobe pathology in the right temporal deficit patients.
在4例精神分裂症患者中，我们研究了临床病程（包括抗精神病药物反应）与以下生物学和心理学指标之间的关系：听觉P300事件相关电位地形图、计算机断层扫描（CT）、安德烈亚森阳性和阴性症状量表、思维障碍指数以及一套神经心理测试。我们实验室之前的两项研究表明，精神分裂症患者与匹配的正常对照组在P300地形图上存在左颞叶头皮区域缺损的差异。本报告比较了两名具有典型左颞叶P300地形图缺损的精神分裂症患者和两名具有右颞叶P300地形图缺损的精神分裂症患者。与两名左颞叶缺损患者相比，两名右颞叶缺损患者有更多的阳性症状、更多的思维障碍、功能受损更严重、起病年龄更早、对抗精神病药物的反应更差、在一套神经心理测试中认知缺陷更广泛，且病前史更差。有一些证据表明，右颞叶缺损患者存在更多提示额叶病变的CT异常。
