Shenton M E, Faux S F, McCarley R W, Ballinger R, Coleman M, Torello M, Duffy F H
Department of Psychiatry, Massachusetts Mental Health Center, Boston.
Biol Psychiatry. 1989 Mar 15;25(6):710-6. doi: 10.1016/0006-3223(89)90242-4.
P300 component amplitude in the left temporal scalp region, shown in three previous studies to differentiate normals from schizophrenics, was found to be significantly correlated with the Thought Disorder Index (TDI) and the Scale for the Assessment of Positive Symptoms (SAPS). These correlations occurred primarily in the P300 waveform derived from the Goodin paradigm. These findings suggest a brain processing disturbance in positive symptom schizophrenia that may be reflected by electrophysiological abnormalities detectable in the temporal scalp region.
先前三项研究表明，左颞头皮区域的P300成分波幅可区分正常人与精神分裂症患者，结果发现其与思维障碍指数（TDI）及阳性症状评定量表（SAPS）显著相关。这些相关性主要出现在源自古丁范式的P300波形中。这些发现提示，阳性症状型精神分裂症存在大脑加工障碍，这可能通过颞头皮区域可检测到的电生理异常反映出来。
