Park Eun-Jung, Pezzuto John M
The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, USA.
The Daniel K. Inouye College of Pharmacy, University of Hawai'i at Hilo, Hilo, HI 96720, USA.
Biochim Biophys Acta. 2015 Jun;1852(6):1071-113. doi: 10.1016/j.bbadis.2015.01.014. Epub 2015 Jan 31.
In addition to thousands of research papers related to resveratrol (RSV), approximately 300 review articles have been published. Earlier research tended to focus on pharmacological activities of RSV related to cardiovascular systems, inflammation, and carcinogenesis/cancer development. More recently, the horizon has been broadened by exploring the potential effect of RSV on the aging process, diabetes, neurological dysfunction, etc. Herein, we primarily focus on the in vivo pharmacological effects of RSV reported over the past 5 years (2009-2014). In addition, recent clinical intervention studies performed with resveratrol are summarized. Some discrepancies exist between in vivo studies with animals and clinical studies, or between clinical studies, which are likely due to disparate doses of RSV, experimental settings, and subject variation. Nevertheless, many positive indications have been reported with mammals, so it is reasonable to advocate for the conduct of more definitive clinical studies. Since the safety profile is pristine, an added advantage is the use of RSV as a dietary supplement. This article is part of a Special Issue entitled: Resveratrol: Challenges in translating pre-clinical findings to improved patient outcomes.
除了数千篇与白藜芦醇（RSV）相关的研究论文外，还发表了约300篇综述文章。早期的研究倾向于关注RSV与心血管系统、炎症以及致癌作用/癌症发展相关的药理活性。最近，通过探索RSV对衰老过程、糖尿病、神经功能障碍等的潜在影响，研究范围得到了拓宽。在此，我们主要关注过去5年（2009 - 2014年）报道的RSV的体内药理作用。此外，还总结了最近用白藜芦醇进行的临床干预研究。动物体内研究与临床研究之间，或临床研究之间存在一些差异，这可能是由于RSV剂量不同、实验设置以及受试者差异所致。然而，在哺乳动物中已报道了许多积极迹象，因此主张开展更具确定性的临床研究是合理的。由于其安全性良好，将RSV用作膳食补充剂还有一个额外的优势。本文是名为：白藜芦醇：将临床前研究结果转化为改善患者预后的挑战的特刊的一部分。
