小儿中枢神经系统胚胎性肿瘤中的微小RNA：已知的未知因素
MicroRNAs in pediatric central nervous system embryonal neoplasms: the known unknown.
作者信息
Braoudaki Maria, Lambrou George I
机构信息
First Department of Pediatrics, University of Athens, Choremeio Research Laboratory, Athens, Greece.
University Research Institute for the Study and Treatment of Childhood Genetic and Malignant Diseases, University of Athens, Aghia Sophia Children's Hospital, Athens, Greece.
出版信息
J Hematol Oncol. 2015 Feb 6;8:6. doi: 10.1186/s13045-014-0101-5.
Abstract
MicroRNAs (miRNAs) are endogenous short non-coding RNAs that repress post-transcriptional regulation of gene expression, while embryonal central nervous system tumors are the foremost cause of mortality in children suffering from a neoplasm. MiRNAs and their regulatory mechanisms are new to understand, while pediatric CNS tumors are difficult to comprehend. Therefore, identification of the link between them composes a major scientific challenge. The present study, reviewed the current knowledge on the role of miRNA in pediatric CNS embryonal tumors, attempting to collect the existing information in one piece of work that could ideally be used as a guide for future reference and research.
摘要
微小RNA（miRNA）是内源性短链非编码RNA，可抑制基因表达的转录后调控，而胚胎中枢神经系统肿瘤是患有肿瘤的儿童死亡的首要原因。miRNA及其调控机制尚待深入了解，小儿中枢神经系统肿瘤也难以理解。因此，确定它们之间的联系构成了一项重大的科学挑战。本研究回顾了关于miRNA在小儿中枢神经系统胚胎性肿瘤中作用的现有知识，试图将现有信息汇总在一项工作中，理想情况下可作为未来参考和研究的指南。
相似文献
1
MicroRNAs in pediatric central nervous system embryonal neoplasms: the known unknown.
J Hematol Oncol. 2015 Feb 6;8:6. doi: 10.1186/s13045-014-0101-5.
2
Microrna expression signatures predict patient progression and disease outcome in pediatric embryonal central nervous system neoplasms.
J Hematol Oncol. 2014 Dec 31;7:96. doi: 10.1186/s13045-014-0096-y.
3
Bioinformatics and Regression Analyses Manifest Tumor-Specific miRNA Expression Dynamics in Pediatric Embryonal Malignancies.
Annu Int Conf IEEE Eng Med Biol Soc. 2018 Jul;2018:5834-5837. doi: 10.1109/EMBC.2018.8513587.
4
MicroRNA signatures as biomarkers and therapeutic target for CNS embryonal tumors: the pros and the cons.
Int J Mol Sci. 2014 Nov 24;15(11):21554-86. doi: 10.3390/ijms151121554.
5
Pediatric primary central nervous system germ cell tumors of different prognosis groups show characteristic miRNome traits and chromosome copy number variations.
BMC Genomics. 2010 Feb 24;11:132. doi: 10.1186/1471-2164-11-132.
6
Advances in the diagnosis, molecular genetics, and treatment of pediatric embryonal CNS tumors.
Oncologist. 2003;8(2):174-86. doi: 10.1634/theoncologist.8-2-174.
7
Mouse models of CNS embryonal tumors.
Brain Tumor Pathol. 2009;26(2):43-50. doi: 10.1007/s10014-009-0253-0. Epub 2009 Oct 27.
8
Role of microRNAs in mammalian spermatogenesis and testicular germ cell tumors.
Reproduction. 2015 Mar;149(3):R127-37. doi: 10.1530/REP-14-0239. Epub 2014 Oct 28.
9
Embryonal Tumors of the Central Nervous System: The WHO 2016 Classification and New Insights.
J Pediatr Hematol Oncol. 2021 Apr 1;43(3):79-89. doi: 10.1097/MPH.0000000000001923.
10
Four Levels of Diagnosis in the Rare Pediatric Embryonal Tumor of the CNS Called Embryonal Tumor with Multilayered Rosettes.
Radiographics. 2018 Mar-Apr;38(2):524. doi: 10.1148/rg.2018184003.
引用本文的文献
1
MicroRNA-Dependent Mechanisms Underlying the Function of a β-Amino Carbonyl Compound in Glioblastoma Cells.
ACS Omega. 2024 Jul 15;9(29):31789-31802. doi: 10.1021/acsomega.4c02991. eCollection 2024 Jul 23.
2
Liquid biopsy in pediatric brain tumors.
Front Genet. 2023 Jan 6;13:1114762. doi: 10.3389/fgene.2022.1114762. eCollection 2022.
3
The role of microRNAs in neurodegenerative diseases: a review.
Cell Biol Toxicol. 2023 Feb;39(1):53-83. doi: 10.1007/s10565-022-09761-x. Epub 2022 Sep 20.
4
MicroRNAs in Methamphetamine-Induced Neurotoxicity and Addiction.
Front Pharmacol. 2022 Apr 14;13:875666. doi: 10.3389/fphar.2022.875666. eCollection 2022.
5
Co-Deregulated miRNA Signatures in Childhood Central Nervous System Tumors: In Search for Common Tumor miRNA-Related Mechanics.
Cancers (Basel). 2021 Jun 17;13(12):3028. doi: 10.3390/cancers13123028.
6
The Role of Liquid Biopsies in Pediatric Brain Tumors.
J Neuropathol Exp Neurol. 2020 Sep 1;79(9):934-940. doi: 10.1093/jnen/nlaa068.
7
Therapeutic approach in glioblastoma multiforme with primitive neuroectodermal tumor components: Case report and review of the literature.
Oncol Lett. 2018 May;15(5):6641-6647. doi: 10.3892/ol.2018.8102. Epub 2018 Feb 21.
8
Aberrant microRNA expression in tumor mycosis fungoides.
Tumour Biol. 2016 Nov;37(11):14667-14675. doi: 10.1007/s13277-016-5325-2. Epub 2016 Sep 13.
9
miR-15a and miR-24-1 as putative prognostic microRNA signatures for pediatric pilocytic astrocytomas and ependymomas.
Tumour Biol. 2016 Jul;37(7):9887-97. doi: 10.1007/s13277-016-4903-7. Epub 2016 Jan 26.
10
MicroRNA expression profiles in pediatric dysembryoplastic neuroepithelial tumors.
Med Oncol. 2016 Jan;33(1):5. doi: 10.1007/s12032-015-0719-3. Epub 2015 Dec 23.
本文引用的文献
1
Elevated circulating microRNA-122 is associated with obesity and insulin resistance in young adults.
Eur J Endocrinol. 2015 Mar;172(3):291-300. doi: 10.1530/EJE-14-0867. Epub 2014 Dec 16.
2
MicroRNA signatures highlight new breast cancer subtypes.
Gene. 2015 Feb 10;556(2):192-8. doi: 10.1016/j.gene.2014.11.053. Epub 2014 Dec 5.
3
miRNA detection methods and clinical implications in lung cancer.
Future Oncol. 2014 Nov;10(14):2279-92. doi: 10.2217/fon.14.93.
4
Detection of circulating hcmv-miR-UL112-3p in patients with glioblastoma, rheumatoid arthritis, diabetes mellitus and healthy controls.
PLoS One. 2014 Dec 2;9(12):e113740. doi: 10.1371/journal.pone.0113740. eCollection 2014.
5
Differences in serum microRNA profiles in hepatitis B and C virus infection.
J Infect. 2015 Mar;70(3):273-87. doi: 10.1016/j.jinf.2014.10.017. Epub 2014 Nov 5.
6
MiRNA profiles in cerebrospinal fluid from patients with central hypersomnias.
J Neurol Sci. 2014 Dec 15;347(1-2):199-204. doi: 10.1016/j.jns.2014.09.047. Epub 2014 Oct 2.
7
MiR-132 prohibits proliferation, invasion, migration, and metastasis in breast cancer by targeting HN1.
Biochem Biophys Res Commun. 2014 Nov 7;454(1):109-14. doi: 10.1016/j.bbrc.2014.10.049. Epub 2014 Oct 17.
8
Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets.
Front Med. 2014 Dec;8(4):404-18. doi: 10.1007/s11684-014-0379-2. Epub 2014 Dec 1.
9
Capillary electrophoresis methods for microRNAs assays: a review.
Anal Chim Acta. 2014 Dec 10;852:1-7. doi: 10.1016/j.aca.2014.08.034. Epub 2014 Aug 21.
10
The role of microRNAs in autoimmune diseases with skin involvement.
Scand J Immunol. 2015 Mar;81(3):153-65. doi: 10.1111/sji.12261.
Zotero 插件