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肌肉骨骼问题与氟暴露:一项针对金属冶炼工人的横断面研究。

Musculoskeletal problems and fluoride exposure: A cross-sectional study among metal smelting workers.

作者信息

Saha A, Mukherjee A K, Ravichandran B

机构信息

Regional Occupational Health Centre (Eastern), Indian Council of Medical Research, Salt Lake, Kolkata, West Bengal, India

Regional Occupational Health Centre (Eastern), Indian Council of Medical Research, Salt Lake, Kolkata, West Bengal, India.

出版信息

Toxicol Ind Health. 2016 Sep;32(9):1581-8. doi: 10.1177/0748233714568477. Epub 2015 Feb 4.

Abstract

Frequent and repetitive activities in job and awkward postures are shown as major contributors of musculoskeletal problems in most of the occupational health studies; however, efforts to explore newer risk factor are important to plan interventional measures. In this backdrop, this study examined contribution of fluoride exposure to musculoskeletal complaints. A cross-sectional interviewer-administered questionnaire survey was conducted involving 180 randomly selected subjects from a metal smelting industry. Clinical examination of the subjects was also performed to assess their health status and morbidity details. Assessment of personal exposure to particulate and gaseous fluoride at workplace was conducted. Urinary fluoride level was also examined in post-shift samples collected from study subjects. The mean age of the study subjects was 39.1 (±6.7) years. Majority of the workers (42.5%) were engaged in pot room. About 54% workers were suffering from backache and 66% subjects had joint pain. Exposure of workers to both particulate and gaseous fluoride and post-working shift urinary fluoride level was significantly higher in pot-room workers in comparison with all other workers. It was observed that age (odds ratio (OR): 1.62; 95% confidence interval (CI): 1.18-2.34), drinking untreated water (OR: 1.51; 95% CI: 1.03-2.76), working in pot room (OR: 1.44; 95% CI: 1.13-1.91) and urinary fluoride level (OR: 2.71; 95% CI: 1.81-3.75) had significant effects on musculoskeletal complaints. This study concludes that along with other predictors such as nature of work, posture at work and age of worker, exposure to fluoride also has significant role in the occurrence of musculoskeletal morbidity.

摘要

在大多数职业健康研究中,工作中的频繁重复活动和不良姿势被视为肌肉骨骼问题的主要成因;然而,探索新的风险因素对于制定干预措施至关重要。在此背景下,本研究调查了氟暴露对肌肉骨骼不适的影响。我们对一家金属冶炼厂随机抽取的180名受试者进行了横断面问卷调查,由访员进行问卷管理。同时对受试者进行了临床检查,以评估他们的健康状况和发病细节。我们还对工作场所的个人颗粒物和气态氟暴露情况进行了评估。从研究对象中收集了班后尿样,检测尿氟水平。研究对象的平均年龄为39.1(±6.7)岁。大多数工人(42.5%)在电解车间工作。约54%的工人有背痛,66%的受试者有关节疼痛。与所有其他工人相比,电解车间工人的颗粒物和气态氟暴露以及班后尿氟水平显著更高。研究发现,年龄(优势比(OR):1.62;95%置信区间(CI):1.18 - 2.34)、饮用未经处理的水(OR:1.51;95%CI:1.03 - 2.76)、在电解车间工作(OR:1.44;95%CI:1.13 - 1.91)和尿氟水平(OR:2.71;95%CI:1.81 - 3.75)对肌肉骨骼不适有显著影响。本研究得出结论,除了工作性质、工作姿势和工人年龄等其他预测因素外,氟暴露在肌肉骨骼疾病的发生中也起着重要作用。

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