Pedersen J, Mølsted-Pedersen L M
Ciba Found Symp. 1978(63):265-71. doi: 10.1002/9780470720462.ch13.
A consecutive and prospective series comprising 949 newborn infants of diabetic mothers treated during pregnancy and delivery in the period 1966--1977 has been analysed. The malformation rate was 8.2%. As compared to infants of mothers (White classes B-F alone) controlled outside pregnancy elsewhere, the rate of malformations was significantly reduced (from 14.1 to 7.4%) in fants whose mothers attended two hospitals specializing in the treatment and ambulatory control of diabetics. For diabetics not controlled at a diabetic centre outside pregnancy the malformation rate was 9% in classes B + C and 19.4% in classes D + F, compared to 6.2 and 8.5%, respectively, for those who were controlled. The rates of malformation (total as well as severe alone) were significantly reduced in infants of White's classes D + F, and insignificantly reduced in classes B + C (in class A no comparison could be made). The findings indicate that poor diabetic control outside pregnancy is teratogenic, although the 'disastrous malformation factor' of diabetes appears not to be totally dependent on the degree of compensation of the disbetic metabolism, as measured by the variables usually applied.
对1966年至1977年期间在孕期和分娩期接受治疗的949例糖尿病母亲的新生儿进行了连续前瞻性研究分析。畸形率为8.2%。与在其他地方孕期未接受控制的母亲（仅White B-F级）的婴儿相比，母亲在两家专门治疗和门诊控制糖尿病的医院就诊的婴儿，其畸形率显著降低（从14.1%降至7.4%）。对于孕期未在糖尿病中心接受控制的糖尿病患者，B + C级的畸形率为9%，D + F级为19.4%，而接受控制的患者分别为6.2%和8.5%。White D + F级婴儿的畸形率（包括总体畸形率和仅严重畸形率）显著降低，B + C级畸形率降低不显著（A级无法进行比较）。研究结果表明，孕期外糖尿病控制不佳具有致畸性，尽管糖尿病的“灾难性畸形因素”似乎并不完全取决于通常所应用变量衡量的糖尿病代谢的代偿程度。
