非黑色素瘤皮肤癌中的Th17细胞因子
Th17 cytokines in non-melanoma skin cancer.
作者信息
McAllister Florencia, Kolls Jay K
机构信息
Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
出版信息
Eur J Immunol. 2015 Mar;45(3):692-4. doi: 10.1002/eji.201545456.
Abstract
T-helper-type 17 cytokines have been implicated in epithelial cancer progression at mucosal sites. In this issue of the European Journal of Immunology, Nardinocchi et al. [Eur. J. Immunol. 2015. 45: 922-931] show that the Th17 cytokines IL-17 and IL-22 can both signal to nonmelanoma skin cancer cells, inducing both cellular proliferation and enhanced migration of human basal cell carcinoma and squamous cell carcinoma cell lines in vitro. These cytokines were also shown to exacerbate tumor growth in mice injected with the squamous cell carcinoma line, CAL27. Thus, IL-17 and IL-22 may be key factors in skin cancer progression and may provide novel prognostic markers in nonmelanoma skin cancer.
摘要
辅助性T细胞17型细胞因子与黏膜部位上皮癌的进展有关。在本期《欧洲免疫学杂志》中，纳尔迪诺基等人[《欧洲免疫学杂志》2015年。45: 922 - 931]表明，Th17细胞因子白细胞介素 - 17（IL - 17）和白细胞介素 - 22（IL - 22）都可以向非黑色素瘤皮肤癌细胞发出信号，在体外诱导人基底细胞癌和鳞状细胞癌细胞系的细胞增殖和迁移增强。这些细胞因子还被证明会加剧注射鳞状细胞癌系CAL27的小鼠的肿瘤生长。因此，IL - 17和IL - 22可能是非黑色素瘤皮肤癌进展的关键因素，并可能为非黑色素瘤皮肤癌提供新的预后标志物。
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