Halliday G M, Patel A, Hunt M J, Tefany F J, Barnetson R S
Department of Dermatology, University of Sydney, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.
World J Surg. 1995 May-Jun;19(3):352-8. doi: 10.1007/BF00299157.
Spontaneous regression occurs in some human malignant melanomas and basal cell carcinomas (BCCs). We have compared the cellular infiltrate in regressing and nonregressing tumors in order to analyze the mechanism by which regression occurs. Regressing primary melanomas and BCCs were infiltrated with a larger number of CD4+, but not CD8+, T lymphocytes than were seen in nonregressing tumors. The number of interleukin 2 receptor-positive (early activation marker) but not transferrin receptor-positive (intermediate activation marker) T cells was increased, indicating that the infiltrating T cells were activated. Large numbers of Langerhans cells, macrophages, and other class II major histocompatibility complex (MHC)-expressing cells were present but were not increased in the regressing tumors. There were no detectable B lymphocytes, and the regressing tumor cells displayed levels of HLA-DR expression similar to those of the nonregressing tumors. Comparison of squamous cell carcinoma (SCCs) with keratoacanthomas (KAs), which are likely to be a spontaneously regressing form of SCC, also showed increased infiltration of activated CD4+, but not CD8+, T cells within the KA. A murine ultraviolet (UV)-induced squamous tumor that spontaneously regresses when transplanted into immunocompetent syngeneic mice was also infiltrated with increased numbers of activated CD4+, but not CD8+, T cells prior to and during rejection. These results indicate that spontaneous regression of human skin tumors is likely to be immunologically mediated, and that CD4+ T lymphocytes seem to mediate this regression.
某些人类恶性黑色素瘤和基底细胞癌（BCC）会发生自发消退。我们比较了消退性肿瘤和非消退性肿瘤中的细胞浸润情况，以分析消退发生的机制。与非消退性肿瘤相比，消退性原发性黑色素瘤和BCC中浸润的CD4⁺ T淋巴细胞数量更多，但CD8⁺ T淋巴细胞数量无差异。白细胞介素2受体阳性（早期激活标志物）的T细胞数量增加，而转铁蛋白受体阳性（中期激活标志物）的T细胞数量未增加，这表明浸润的T细胞被激活。大量朗格汉斯细胞、巨噬细胞和其他表达II类主要组织相容性复合体（MHC）的细胞存在，但在消退性肿瘤中数量并未增加。未检测到B淋巴细胞，且消退性肿瘤细胞的HLA - DR表达水平与非消退性肿瘤相似。将鳞状细胞癌（SCC）与角化棘皮瘤（KA）进行比较，KA可能是SCC的一种自发消退形式，结果也显示KA内激活的CD4⁺ T细胞浸润增加，但CD8⁺ T细胞无此现象。一种小鼠紫外线（UV）诱导的鳞状肿瘤，当移植到具有免疫活性的同基因小鼠体内时会自发消退，在排斥反应之前和期间，其浸润的激活CD4⁺ T细胞数量也增加，但CD8⁺ T细胞无此现象。这些结果表明，人类皮肤肿瘤的自发消退可能是由免疫介导的，且CD4⁺ T淋巴细胞似乎介导了这种消退。
