Derya Mehmet Ali, Demir Vahit, Ede Huseyin
Cardiology Department, Faculty of Medicine, 485513 Bozok University, Yozgat , Turkey.
J Int Med Res. 2018 Mar;46(3):940-950. doi: 10.1177/0300060517749130. Epub 2018 Jan 14.
Objective Epicardial fat tissue thickness (EFT) and the neutrophil/lymphocyte ratio (NLR) are associated with atherosclerosis. Few studies have focused on the relationship between these parameters in patients with newly diagnosed hypertension. In this study, we examined the relationship between EFT and the NLR in patients with newly diagnosed hypertension detected by 24-hour ambulatory blood pressure monitoring (ABPM). Methods Eighty consecutive patients without chronic illness who were diagnosed with hypertension according to ABPM results and 80 otherwise healthy subjects were enrolled in the study. EFT of each participant was measured echocardiographically. The C-reactive protein (CRP) concentration and NLR were measured from venous blood samples. Results The 24-hour average systolic blood pressure was significantly higher in the hypertension group than in the control group (143±17 vs. 117±7 mmHg, respectively). There were no significant differences in age, sex, or body mass index between the two groups. EFT, the NLR, and the CRP concentration were significantly higher in the hypertension group than control group. Additionally, a significantly positive correlation between EFT and the NLR was found in both the control group and hypertension group. Conclusion A higher EFT and NLR were detected in patients with newly diagnosed hypertension than in healthy subjects.
目的 心外膜脂肪组织厚度（EFT）和中性粒细胞/淋巴细胞比值（NLR）与动脉粥样硬化相关。鲜有研究关注新诊断高血压患者中这些参数之间的关系。在本研究中，我们通过24小时动态血压监测（ABPM）检测新诊断高血压患者的EFT与NLR之间的关系。方法 连续纳入80例根据ABPM结果诊断为高血压且无慢性病的患者以及80例健康对照者。通过超声心动图测量每位参与者的EFT。从静脉血样本中检测C反应蛋白（CRP）浓度和NLR。结果 高血压组24小时平均收缩压显著高于对照组（分别为143±17 mmHg和117±7 mmHg）。两组在年龄、性别或体重指数方面无显著差异。高血压组的EFT、NLR和CRP浓度显著高于对照组。此外，在对照组和高血压组中均发现EFT与NLR之间存在显著正相关。结论 新诊断高血压患者的EFT和NLR高于健康受试者。
