Sun Jiehao, Wu Xiuying, Zhao Xiyue, Chen Feifei, Wang Weijian
Department of Anesthesiology, 1st Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.
Department of Anesthesiology, Shengjing Hospital, China Medical University, Shenyang, China.
Int J Pediatr Otorhinolaryngol. 2015 Apr;79(4):499-503. doi: 10.1016/j.ijporl.2015.01.009. Epub 2015 Jan 16.
The randomized, double-blinded, placebo-controlled study evaluated the administration of local infiltration of magnesium combined with ropivacaine to reduce pain scores after pediatric adenotonsillectomy.
Sixty one subjects received 5ml solution contained 0.25% ropivacaine plus 5mg/kg magnesium sulphate (Group M+R), 5ml 0.25% ropivacaine (Group R) or 5ml solution contained 5mg/kg magnesium sulphate (Group M). Pain scores in the ward and at home, analgesics received after operation and the adverse effects were recorded.
Compared with group M, patients in group M+R and group R had lower pain scores, less emergence agitation and increased time for first analgesic request. Group M+R had no benefit in reducing pain scores after adenotonsillectomy compared with group R.
Pre-emptive peritonsillar infiltration of magnesium sulphate 5mg/kg combined with 0.25% ropivacaine couldn't improve analgesia for pediatric adenotonsillectomy compared with 0.25% ropivacaine alone. However, Group M+R had less incidence of emergence agitation. Compared with group M, both of group M+R and group R had better postoperative analgesia.
