Cantley Alexandra M, Clardy Jon
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.
Nat Prod Rep. 2015 Jul;32(7):888-92. doi: 10.1039/c4np00141a.
This Viewpoint article provides a brief and selective summary of research on the chemical ecology underlying symbioses between bacteria and animals. Animals engage in multiple highly specialized interactions with bacteria that reflect their long coevolutionary history. The article focuses on a few illustrative but hardly exhaustive examples in which bacterially produced small molecules initiate a developmental step with important implications for the evolution of animals, provide signals for the maturation of mammalian immune systems, and furnish chemical defenses against microbial pathogens.
这篇观点文章简要且有选择性地总结了关于细菌与动物共生关系背后化学生态学的研究。动物与细菌进行多种高度专业化的相互作用，这反映了它们漫长的共同进化历史。本文聚焦于一些具有代表性但远非详尽无遗的例子，其中细菌产生的小分子引发了对动物进化具有重要意义的发育步骤，为哺乳动物免疫系统的成熟提供信号，并提供针对微生物病原体的化学防御。
