La Rue Asenath, Felten Kristen, Turkstra Lyn
Wisconsin Alzheimer's Institute, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI, USA
Office on Aging, Wisconsin Department of Health Services, Madison, WI, USA.
Am J Alzheimers Dis Other Demen. 2015 Aug;30(5):468-77. doi: 10.1177/1533317514568888. Epub 2015 Feb 4.
A Language-Enriched Exercise Plus Socialization (LEEPS) Program for older adults with Alzheimer's disease and related disorders (ADRD) was implemented in rural Wisconsin communities. Patterned after a university-based research intervention, (1) the LEEPS protocol entailed ongoing weekly to biweekly sessions with a trained volunteer and an individual with dementia, with exercise and language stimulation sessions interspersed with social or volunteer outings. Of 64 persons with ADRD who enrolled, 29 completed an initial follow-up assessment at an average of 10.65 months, and 8 completed a second follow-up at an average of 20.55 months. Results generally show stability in cognition, mood, and physical performance. Improvement was noted at the initial retest on 1 of the 3 physical fitness measures (arm curls; t = 2.61, P = .015), but self-rated quality of life declined slightly from baseline to the first retest (t = -2.09, P = .048). Change in the Mini-Mental State Examination at the first and second follow-ups (mean = +0.18 and -1.0, respectively) was negligible. The maintenance of function observed with LEEPS is an encouraging outcome, given the progressive nature of ADRD, but controlled investigations are needed to establish the efficacy of LEEPS. Barriers to implementation of an intensive activities-focused intervention in rural communities are discussed.
一项针对患有阿尔茨海默病及相关疾病(ADRD)的老年人的语言强化锻炼与社交(LEEPS)项目在威斯康星州农村社区实施。该LEEPS方案仿照一项基于大学的研究干预措施制定,(1)包括与一名经过培训的志愿者和一名患有痴呆症的个体每周至每两周进行一次持续的会面,锻炼和语言刺激课程穿插着社交或志愿者外出活动。在登记的64名患有ADRD的人中,29人在平均10.65个月时完成了首次随访评估,8人在平均20.55个月时完成了第二次随访。结果总体显示认知、情绪和身体表现保持稳定。在3项体能测量指标中的1项(手臂卷曲;t = 2.61,P = .015)的首次复测中发现有改善,但从基线到首次复测,自评生活质量略有下降(t = -2.09,P = .048)。在第一次和第二次随访时简易精神状态检查的变化(平均值分别为+0.18和-1.0)可忽略不计。鉴于ADRD的渐进性,LEEPS观察到的功能维持是一个令人鼓舞的结果,但需要进行对照研究以确定LEEPS的疗效。讨论了在农村社区实施以密集活动为重点的干预措施的障碍。