体育锻炼对轻度认知障碍和痴呆症的生化标志物：系统评价与展望
Biochemical Markers of Physical Exercise on Mild Cognitive Impairment and Dementia: Systematic Review and Perspectives.
作者信息
Jensen Camilla Steen, Hasselbalch Steen Gregers, Waldemar Gunhild, Simonsen Anja Hviid
机构信息
Department of Neurology, Danish Dementia Research Centre, Rigshospitalet - Copenhagen University Hospital , Copenhagen , Denmark.
Department of Neurology, Danish Dementia Research Centre, Rigshospitalet - Copenhagen University Hospital , Copenhagen , Denmark ; Department of Clinical Medicine, University of Copenhagen , Copenhagen , Denmark.
出版信息
Front Neurol. 2015 Aug 26;6:187. doi: 10.3389/fneur.2015.00187. eCollection 2015.
BACKGROUND
The cognitive effects of physical exercise in patients with dementia disorders or mild cognitive impairment have been examined in various studies; however the biochemical effects of exercise from intervention studies are largely unknown. The objective of this systematic review is to investigate the published results on biomarkers in physical exercise intervention studies in patients with MCI or dementia.
METHODS
The PubMed database was searched for studies from 1976 to February 2015. We included intervention studies investigating the effect of physical exercise activity on biomarkers in patients with MCI or dementia.
RESULTS
A total of eight studies were identified (n = 447 patients) evaluating exercise regimes with variable duration (single session-three sessions/week for 26 weeks) and intensity (light-resistance training-high-intensity aerobic exercise). Various biomarkers were measured before and after intervention. Seven of the eight studies found a significant effect on their selected biomarkers with a positive effect of exercise on brain-derived neurotrophic factor, cholesterol, testosterone, estradiol, dehydroepiadrosterone, and insulin in the intervention groups compared with controls.
CONCLUSION
Although few studies suggest a beneficial effect on selected biomarkers, we need more knowledge of the biochemical effect of physical exercise in dementia or MCI.
背景
在多项研究中已对体育锻炼对痴呆症患者或轻度认知障碍患者认知功能的影响进行了研究；然而，干预研究中锻炼的生化效应在很大程度上尚不清楚。本系统评价的目的是调查关于轻度认知障碍（MCI）或痴呆症患者体育锻炼干预研究中生物标志物的已发表结果。
方法
在PubMed数据库中检索1976年至2015年2月的研究。我们纳入了调查体育锻炼活动对MCI或痴呆症患者生物标志物影响的干预研究。
结果
共确定了八项研究（n = 447例患者），评估了持续时间（单次 - 每周三次，共26周）和强度（轻度抗阻训练 - 高强度有氧运动）各不相同的锻炼方案。在干预前后测量了各种生物标志物。八项研究中的七项发现，与对照组相比，干预组中锻炼对其选定的生物标志物有显著影响，锻炼对脑源性神经营养因子、胆固醇、睾酮、雌二醇、脱氢表雄酮和胰岛素有积极作用。
结论
尽管少数研究表明对选定的生物标志物有有益影响，但我们需要更多关于体育锻炼对痴呆症或MCI生化效应的知识。
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