Yan Hualin, Hong Peiwei, Jiang Mei, Li Hedong
West China Developmental & Stem Cell Institute, Department of Obstetric & Gynecologic and Pediatric, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China ; West China Medical School, Sichuan University, Chengdu 610041, Sichuan Province, China.
West China Developmental & Stem Cell Institute, Department of Obstetric & Gynecologic and Pediatric, Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects, Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
Neural Regen Res. 2012 Jun 15;7(17):1352-9. doi: 10.3969/j.issn.1673-5374.2012.17.011.
MicroRNAs are a class of recently discovered, small non-coding RNAs that have been shown to play essential roles in a vast majority of biological processes. Very little is known about the role of microRNAs during spinal cord injury. This review summarizes the changes in expression levels of microRNAs after spinal cord injury. These aberrant changes suggest that microRNAs play an important role in inflammation, oxidative stress, apoptosis, glial scar formation and axonal regeneration. Given their small size and specificity of action, microRNAs could be potential therapeutics for treating spinal cord injury in the future. There are rapidly developing techniques for manipulating microRNA levels in animals; we review different chemical modification and delivery strategies. These may provide platforms for designing efficient microRNA delivery protocols for use in the clinic.
微小RNA是一类最近发现的小型非编码RNA，已被证明在绝大多数生物过程中发挥着重要作用。关于微小RNA在脊髓损伤中的作用，目前所知甚少。这篇综述总结了脊髓损伤后微小RNA表达水平的变化。这些异常变化表明，微小RNA在炎症、氧化应激、细胞凋亡、胶质瘢痕形成和轴突再生中发挥着重要作用。鉴于其体积小和作用特异性，微小RNA未来可能成为治疗脊髓损伤的潜在疗法。目前有快速发展的技术可用于在动物体内调控微小RNA水平；我们综述了不同的化学修饰和递送策略。这些可能为设计用于临床的高效微小RNA递送方案提供平台。
