Hu Baoyang, Zhao Yue, Chen Chao, Wu Bin, Zhang Hongbin, Liu Bin, Zheng Runquan, Fang Fang
Spinal Surgery, Tongliao People's Hospital, Tongliao, Inner Mongolia, China.
Computer Network Information Center, Tongliao People's Hospital, Tongliao, Inner Mongolia, China.
Front Neurol. 2024 May 21;15:1406977. doi: 10.3389/fneur.2024.1406977. eCollection 2024.
Spinal cord injury (SCI) is a nervous system disease leading to motor and sensory dysfunction below the injury level, and can result in paralysis. MicroRNAs (miRNAs) play a key role in SCI treatment, and related research provides insights for SCI diagnosis and treatment. Bibliometrics is an important tool for literature statistics and evaluation, objectively summarizing multidimensional information. This study comprehensively overviews the field through bibliometric analysis of miRNA and SCI research, providing contemporary resources for future collaboration and clinical treatment.
In this study, we searched the Web of Science Core Collection (WOSCC) database. After careful screening and data import, we extracted annual publications, citation counts, countries, institutions, authors, journals, highly cited articles, co-cited articles, keywords, and H-index. Bibliometrics and visualization analyses employed VOSviewer, CiteSpace, the R package "bibliometrix," and online analytic platforms. Using Arrowsmith, we determined miRNA-SCI relationships and discussed potential miRNA mechanisms in SCI.
From 2008 to 2024, the number of related papers increased annually, reaching 754. The number of yearly publications remained high and entered a period of rapid development. Researchers from 50 countries/regions, 802 institutions, 278 journals, and 3,867 authors participated in the field. Currently, China has advantages in the number of national papers, citations, institutions, and authors. However, it is necessary to strengthen cooperation among different authors, institutions, and countries to promote the production of important academic achievements. The research in the field currently focuses on nerve injury, apoptosis, and gene expression. Future research directions mainly involve molecular mechanisms, clinical trials, exosomes, and inflammatory reactions.
Overall, this study comprehensively analyzes the research status and frontier of miRNAs in SCI. A systematic summary provides a complete and intuitive understanding of the relationship between SCI and miRNAs. The presented findings establish a basis for future research and clinical application in this field.
脊髓损伤（SCI）是一种导致损伤平面以下运动和感觉功能障碍的神经系统疾病，可导致瘫痪。微小RNA（miRNA）在SCI治疗中起关键作用，相关研究为SCI的诊断和治疗提供了思路。文献计量学是文献统计和评价的重要工具，能客观地概括多维度信息。本研究通过对miRNA与SCI研究的文献计量分析全面概述该领域，为未来合作和临床治疗提供当代资源。
在本研究中，我们检索了Web of Science核心合集（WOSCC）数据库。经过仔细筛选和数据导入后，我们提取了年度出版物、被引频次、国家、机构、作者、期刊、高被引文章、共被引文章、关键词和H指数。使用VOSviewer、CiteSpace、R包“bibliometrix”和在线分析平台进行文献计量学和可视化分析。利用Arrowsmith确定miRNA与SCI的关系，并讨论SCI中潜在的miRNA机制。
2008年至2024年，相关论文数量逐年增加，达到754篇。年度出版物数量居高不下并进入快速发展阶段。来自50个国家/地区、802个机构、278种期刊和3867位作者参与了该领域的研究。目前，中国在国家论文数量、被引频次、机构和作者数量方面具有优势。然而，有必要加强不同作者、机构和国家之间的合作，以促进重要学术成果的产出。该领域目前的研究重点是神经损伤、细胞凋亡和基因表达。未来的研究方向主要涉及分子机制、临床试验、外泌体和炎症反应。
总体而言，本研究全面分析了miRNA在SCI中的研究现状和前沿。系统总结为全面直观地理解SCI与miRNA之间的关系提供了帮助。所呈现的研究结果为该领域未来的研究和临床应用奠定了基础。
